PAX4 and FBXO2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PAX4	FBXO2
Description		paired box 4	F-box protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Endoplasmic Reticulum Cytosol Membrane SCF Ubiquitin Ligase Complex Dendritic Spine Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding Sequence-specific Double-stranded DNA Binding	Amyloid-beta Binding Ubiquitin-protein Transferase Activity Protein Binding Carbohydrate Binding Denatured Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Type B Pancreatic Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Sensory Organ Development Animal Organ Morphogenesis Cell Differentiation Forebrain Development Animal Organ Development Retina Development In Camera-type Eye	Proteolysis Ubiquitin-dependent Protein Catabolic Process Glycoprotein Catabolic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Protein Modification Process ERAD Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Fruit consumption ( 32066663) Left-handedness ( 32989287) Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Type 2 diabetes ( 22158537 23532257 26818947 29632382 30718926 32499647 32794382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		14 interacting genes: AURKA CABP5 EIF4A3 FBXO2 GMCL1 NAIF1 NECAB1 NFYC NME7 NRXN3 NTM NUTF2 PSMC1 UBL5	16 interacting genes: AHSG BACE1 BRAP ECPAS IGH ITGB1 PAX4 PFDN6 SKP1 STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 VSTM1
Entrez ID		5078	26232
HPRD ID		01333	06171
Ensembl ID		ENSG00000106331	ENSG00000116661
Uniprot IDs		A0A1W2PPX4 J3KPG0	Q9UK22
PDB IDs
Enriched GO Terms of Interacting Partners?			Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Monoubiquitination Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Protein Autoubiquitination Protein Modification Process Proteasomal Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Vasoconstriction Positive Regulation Of Protein Ubiquitination Catabolic Process Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Folding Chaperone Complex Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transferase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Myoblast Fate Specification Integrin Alpha7-beta1 Complex Nucleoplasm Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Chaperone-mediated Protein Complex Assembly Multivesicular Body Golgi-associated Vesicle Lumen Negative Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Integrin Alpha6-beta1 Complex Regulation Of Vasoconstriction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Positive Regulation Of Programmed Cell Death Integrin Alpha1-beta1 Complex
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