ACAP1 and FCHSD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACAP1	FCHSD2
Description		ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	FCH and double SH3 domains 2
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GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Recycling Endosome Membrane	Cytoplasm Plasma Membrane Clathrin-coated Pit Membrane Neuromuscular Junction Stereocilium Cell Projection Recycling Endosome Anchoring Junction Stereocilium Shaft
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Protein Transport	Endocytosis Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Membrane Organization Clathrin-dependent Endocytosis Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33272962 33536424) White blood cell count ( 32888494)	Albumin-globulin ratio ( 29403010) Crohn's disease ( 23266558 23850713) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Nicotine dependence symptom count ( 25555482) Serum total protein levels ( 29403010) Systemic lupus erythematosus ( 26663301 33272962)
Interacting Genes		12 interacting genes: AKT1 FCHSD2 GRB2 IFFO1 ITGB1 NEBL RABGAP1L SH3RF1 SNCA TFRC UQCRB VAMP3	52 interacting genes: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CIMIP6 CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587
Entrez ID		9744	9873
HPRD ID		08474	13321
Ensembl ID		ENSG00000072818	ENSG00000137478
Uniprot IDs		Q15027	O94868
PDB IDs		3JUE 3T9K 4CKG 4CKH 4F1P 4NSW 5H3D	2DL5 2DL7 6GBU
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Receptor Internalization Receptor-mediated Endocytosis Endocytosis Import Into Cell Recycling Endosome Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Protein Localization To Cell Periphery SNARE Complex Assembly Positive Regulation Of Receptor Recycling Regulation Of Cell Activation Positive Regulation Of Fibroblast Migration Perinuclear Region Of Cytoplasm Regulation Of Neurotransmitter Uptake Endosome Regulation Of T Cell Activation Regulation Of Receptor Recycling Phosphatidylinositol-3,4-bisphosphate Binding Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Protein Localization To Cell Periphery Cell Cortex Protein Kinase Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Localization Positive Regulation Of Protein Localization Negative Regulation Of Programmed Cell Death Regulation Of Protein-containing Complex Assembly Organelle Localization Response To Iron Ion Response To Copper Ion Lamellipodium Golgi To Plasma Membrane Protein Transport Blood Vessel Endothelial Cell Migration Cellular Response To Lipoprotein Particle Stimulus Phosphatidylinositol-3,4,5-trisphosphate Binding Positive Regulation Of Organelle Organization Regulation Of Lymphocyte Activation Regulation Of Immune System Process Regulation Of Fibroblast Migration Response To Cytokine T Cell Costimulation Response To Peptide Postsynapse Positive Regulation Of Actin Filament Polymerization Hsp70 Protein Binding Protein Transport Positive Regulation Of Cellular Component Organization	TPR Domain Binding Clathrin-dependent Synaptic Vesicle Endocytosis Cytoplasm
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