ACAP1 and VAMP3

Number of citations of the paper that reports this interaction (PubMedID 15525538)
0

Data Source:
HPRD (in vitro, in vivo)

		ACAP1	VAMP3
Description		ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	vesicle associated membrane protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Recycling Endosome Membrane	Endosome Early Endosome Cytosol Plasma Membrane Cell Surface Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Neuron Projection Intracellular Membrane-bounded Organelle Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding
	Biological Process	Protein Transport	Positive Regulation Of Receptor Recycling Positive Regulation Of Immunoglobulin Production Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Cellular Response To Type II Interferon Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell
Pathways			ER-Phagosome pathway Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33272962 33536424) White blood cell count ( 32888494)	Crohn's disease ( 21102463 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Morning vs. evening chronotype ( 26835600) Periodontal microbiota ( 22699663) Ulcerative colitis ( 28067908)
Interacting Genes		12 interacting genes: AKT1 FCHSD2 GRB2 IFFO1 ITGB1 NEBL RABGAP1L SH3RF1 SNCA TFRC UQCRB VAMP3	63 interacting genes: ACAP1 AHNAK2 AIG1 APP AQP6 ARL13B BCAP31 BCL2L13 BIK BSCL2 BSND CD79A CIAO2A CLDN7 CLEC14A COMT DDB1 DNAJC5 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B GORAB GPX8 HSD17B13 IKBKG KCNK5 LHFPL5 LMNA MGST2 MGST3 NELFE NEMP1 PDZK1IP1 PLEKHO1 PTGES RETREG3 RMDN3 SAR1A SCN3B SLC10A1 SLC10A6 SLC16A2 SNAP23 STX16 STX1A STX2 STX3 STX4 TM4SF19 TM4SF20 TMEM237 TMEM31 TMEM35A TMEM52B TMEM86B TMPPE TMX2 VAMP2 VEGFD VSIR
Entrez ID		9744	9341
HPRD ID		08474	04711
Ensembl ID		ENSG00000072818	ENSG00000049245
Uniprot IDs		Q15027	Q15836 Q6FGG2
PDB IDs		3JUE 3T9K 4CKG 4CKH 4F1P 4NSW 5H3D
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Receptor Internalization Receptor-mediated Endocytosis Endocytosis Import Into Cell Recycling Endosome Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Protein Localization To Cell Periphery SNARE Complex Assembly Positive Regulation Of Receptor Recycling Regulation Of Cell Activation Positive Regulation Of Fibroblast Migration Perinuclear Region Of Cytoplasm Regulation Of Neurotransmitter Uptake Endosome Regulation Of T Cell Activation Regulation Of Receptor Recycling Phosphatidylinositol-3,4-bisphosphate Binding Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Protein Localization To Cell Periphery Cell Cortex Protein Kinase Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Localization Positive Regulation Of Protein Localization Negative Regulation Of Programmed Cell Death Regulation Of Protein-containing Complex Assembly Organelle Localization Response To Iron Ion Response To Copper Ion Lamellipodium Golgi To Plasma Membrane Protein Transport Blood Vessel Endothelial Cell Migration Cellular Response To Lipoprotein Particle Stimulus Phosphatidylinositol-3,4,5-trisphosphate Binding Positive Regulation Of Organelle Organization Regulation Of Lymphocyte Activation Regulation Of Immune System Process Regulation Of Fibroblast Migration Response To Cytokine T Cell Costimulation Response To Peptide Postsynapse Positive Regulation Of Actin Filament Polymerization Hsp70 Protein Binding Protein Transport Positive Regulation Of Cellular Component Organization	Membrane SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Organelle Fusion Glutathione Peroxidase Activity Membrane Fusion Vesicle Docking Exocytosis Organelle Localization By Membrane Tethering SNARE Complex Assembly Secretion By Cell Specific Granule Vesicle Organization Membrane Docking Endoplasmic Reticulum Membrane Signal Release Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Positive Regulation Of Protein Localization To Cell Surface Endomembrane System Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum Secretion Membrane Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Glutathione Transferase Activity Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Cellular Oxidant Detoxification Synaptic Vesicle Exocytosis ATP-dependent Protein Binding Prostanoid Metabolic Process Establishment Of Localization In Cell Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Vesicle-mediated Transport In Synapse Unsaturated Fatty Acid Metabolic Process Regulation Of Protein Localization To Cell Surface Icosanoid Metabolic Process Protein Transport Icosanoid Biosynthetic Process Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutathione Binding Cellular Detoxification Nuclear Envelope Lumen
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