ACAP1 and UQCRB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACAP1	UQCRB
Description		ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	ubiquinol-cytochrome c reductase binding protein
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GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Recycling Endosome Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Transport	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Cellular Respiration
Pathways			Respiratory electron transport Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Autoimmune thyroid disease ( 32581359) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33272962 33536424) White blood cell count ( 32888494)	Huntington's disease progression ( 28642124)
Interacting Genes		12 interacting genes: AKT1 FCHSD2 GRB2 IFFO1 ITGB1 NEBL RABGAP1L SH3RF1 SNCA TFRC UQCRB VAMP3	9 interacting genes: ACAP1 ACCS HPCA HSPB1 LRRK2 MAGEA1 MAGEA4 MAGEB4 ZSWIM7
Entrez ID		9744	7381
HPRD ID		08474	11770
Ensembl ID		ENSG00000072818	ENSG00000156467
Uniprot IDs		Q15027	P14927
PDB IDs		3JUE 3T9K 4CKG 4CKH 4F1P 4NSW 5H3D	5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Receptor Internalization Receptor-mediated Endocytosis Endocytosis Import Into Cell Recycling Endosome Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Protein Localization To Cell Periphery SNARE Complex Assembly Positive Regulation Of Receptor Recycling Regulation Of Cell Activation Positive Regulation Of Fibroblast Migration Perinuclear Region Of Cytoplasm Regulation Of Neurotransmitter Uptake Endosome Regulation Of T Cell Activation Regulation Of Receptor Recycling Phosphatidylinositol-3,4-bisphosphate Binding Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Protein Localization To Cell Periphery Cell Cortex Protein Kinase Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Localization Positive Regulation Of Protein Localization Negative Regulation Of Programmed Cell Death Regulation Of Protein-containing Complex Assembly Organelle Localization Response To Iron Ion Response To Copper Ion Lamellipodium Golgi To Plasma Membrane Protein Transport Blood Vessel Endothelial Cell Migration Cellular Response To Lipoprotein Particle Stimulus Phosphatidylinositol-3,4,5-trisphosphate Binding Positive Regulation Of Organelle Organization Regulation Of Lymphocyte Activation Regulation Of Immune System Process Regulation Of Fibroblast Migration Response To Cytokine T Cell Costimulation Response To Peptide Postsynapse Positive Regulation Of Actin Filament Polymerization Hsp70 Protein Binding Protein Transport Positive Regulation Of Cellular Component Organization	Response To Ketamine Dendrite Cytoplasm Negative Regulation Of Protein Kinase C Signaling Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway 1-aminocyclopropane-1-carboxylate Synthase Activity Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Shu Complex Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Positive Regulation Of Protein Autoubiquitination Response To Curcumin Perikaryon Response To Aroclor 1254 Dendritic Spine Head Regulation Of Protein Kinase C Signaling Histone Deacetylase Binding Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Regulation Of Kidney Size Tangential Migration From The Subventricular Zone To The Olfactory Bulb Calcium-mediated Signaling Cellular Response To Metal Ion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Synaptic Vesicle Recycling Cellular Response To Dopamine Intracellular Distribution Of Mitochondria Regulation Of Retrograde Transport, Endosome To Golgi Cellular Response To L-glutamate Anterograde Axonal Protein Transport Regulation Of Intrinsic Apoptotic Signaling Pathway JUN Kinase Kinase Kinase Activity Positive Regulation Of Microglial Cell Activation
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