HDAC9 and SYK

Number of citations of the paper that reports this interaction (PubMedID 16288017)
38

Data Source:
BioGRID (affinity chromatography technology, pull down)

		HDAC9	SYK
Description		histone deacetylase 9	spleen associated tyrosine kinase
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Histone Methyltransferase Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane B Cell Receptor Complex Early Phagosome Protein-containing Complex T Cell Receptor Complex
	Molecular Function	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Histone H3K14 Deacetylase Activity, Hydrolytic Mechanism Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone H4K16 Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Interleukin-15 Receptor Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Toll-like Receptor Binding SH2 Domain Binding Phospholipase Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Chromatin Organization Inflammatory Response Heart Development Negative Regulation Of Macromolecule Biosynthetic Process B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Cholesterol Homeostasis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Autophagosome Assembly Angiogenesis Cell Activation Positive Regulation Of Cytokine Production Serotonin Secretion Lymph Vessel Development Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Serotonin Secretion By Platelet Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Protein Import Into Nucleus Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Integrin-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Platelet Activation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Leukotriene Biosynthetic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Neutrophil Chemotaxis Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Cellular Response To Nutrient Levels Positive Regulation Of Type I Interferon Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-3 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Interleukin-3-mediated Signaling Pathway TORC1 Signaling Gamma-delta T Cell Differentiation Defense Response To Bacterium Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of DNA-binding Transcription Factor Activity Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Cellular Response To Lipid Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Arachidonate Secretion Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Amyloid-beta Cellular Response To Lectin
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway	GPVI-mediated activation cascade GPVI-mediated activation cascade FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis DAP12 signaling Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Integrin signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Interleukin-2 signaling Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Valproic acid Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide	Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide Tamatinib 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic acid Fostamatinib Entospletinib
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid angiopathy ( 25188341) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Coronary artery disease ( 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Cortical surface area (visual PC2) ( 32198502) Cortical volume ( 32963231) Depressive symptom (fatigue) (ordinal trait) ( 31530331) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Fasting blood glucose ( 31217584) Fasting glucose ( 34074324) Height ( 31562340) Iris color (b* coordinate) ( 30895295) Ischemic stroke ( 26708676) Ischemic stroke (large artery atherosclerosis) ( 26708676) Large artery stroke ( 28265093 24262325) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Late-onset Alzheimer's disease ( 27770636) Loneliness ( 27629369) Male-pattern baldness ( 27182965 22693459 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 31628463) Moderate-to-late spontaneous preterm birth ( 31194736) Monobrow ( 27182965) Moyamoya disease ( 29273593) Myocardial infarction ( 33532862) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30374069) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Peripheral artery disease ( 31285632 26488411) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 29403010 28739976 26390057 27841878 30487518) Reading disability ( 32108986) Reasoning ( 29907492) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Response to lithium treatment in bipolar disorder (continuous phenotype) ( 26806518) Resting-state electroencephalogram vigilance ( 29703947) Retinopathy in non-diabetics ( 23393555) Stroke ( 26089329 22306652) Stroke (ischemic) ( 23041239) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Systolic blood pressure ( 27841878 30487518) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 20848476) Zinc levels ( 26025379)	Alzheimer's disease ( 30636644) Anti-saccade response ( 29064472) Atrial fibrillation ( 28416822) Chromosomal aberration frequency (total) ( 31586183) Frontal pole volume ( 31530798) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)
Interacting Genes		30 interacting genes: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 H3C15 H4C16 HDAC1 HDAC3 HDAC4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 NRIP1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SYK TRIM29 USF1 YWHAZ ZBTB16	110 interacting genes: APP AR BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CEBPA COASY CRKL CRYAA CSF2RB CSF3R CTTN DBNL DPP9 DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB1 GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HGS HNRNPU IL15RA IL2RB ITGB2 JAK1 KIT LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MET MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RHOU RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TRIM15 TRIM31 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2
Entrez ID		9734	6850
HPRD ID		05944	02514
Ensembl ID		ENSG00000048052	ENSG00000165025
Uniprot IDs		A0A7P0T8F4 A0A7P0TAB5 A0A9L9PXL9 B7Z3P7 Q9UKV0	C3W981 P43405
PDB IDs		8Q9N 8Q9R	1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG 4I0R 4I0S 4I0T 4PUZ 4PV0 4PX6 4RSS 4RX7 4RX8 4RX9 4WNM 4XG2 4XG3 4XG4 4XG6 4XG7 4XG8 4XG9 4YJO 4YJP 4YJQ 4YJR 4YJS 4YJT 4YJU 4YJV 5C26 5C27 5CXH 5CXZ 5CY3 5GHV 5LMA 5LMB 5T68 5TIU 5TR6 5TT7 5Y5T 5Y5U 6HM6 6HM7 6SSB 6VOV 6ZC0 6ZCP 6ZCQ 6ZCR 6ZCS 6ZCU 6ZCX 6ZCY 7Q5T 7Q5U 7Q5W 7Q63 7SA7 8BI2 8RRQ 8RRZ 8WYW 8X5K 8XQ0 8XQ1 8XQ2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Repressor Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Histone Deacetylase Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleus DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Nucleoplasm Transcription Corepressor Binding Chromatin Binding Rhythmic Process Positive Regulation Of RNA Metabolic Process Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process JUN Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process Fc-epsilon Receptor Signaling Pathway MAPK Cascade Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Protein Kinase Binding Chromatin Organization Chromatin Remodeling	Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Leukocyte Activation Cell Activation Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Lymphocyte Activation Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cell Activation Activation Of Immune Response Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Effector Process B Cell Activation Cellular Developmental Process Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Population Proliferation Intracellular Signaling Cassette Membrane Raft Cytokine-mediated Signaling Pathway Regulation Of Developmental Process Regulation Of Programmed Cell Death Leukocyte Differentiation Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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