HDAC9 and CBX5

Number of citations of the paper that reports this interaction (PubMedID 12242305)
50

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		HDAC9	CBX5
Description		histone deacetylase 9	chromobox 5
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Histone Methyltransferase Complex	Histone Deacetylase Complex Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Histone H3K14 Deacetylase Activity, Hydrolytic Mechanism Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone H4K16 Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Histone H3K9me2/3 Reader Activity DNA-binding Transcription Factor Binding Histone Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Chromatin Organization Inflammatory Response Heart Development Negative Regulation Of Macromolecule Biosynthetic Process B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Cholesterol Homeostasis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs		Valproic acid Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide	Copper
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid angiopathy ( 25188341) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Coronary artery disease ( 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Cortical surface area (visual PC2) ( 32198502) Cortical volume ( 32963231) Depressive symptom (fatigue) (ordinal trait) ( 31530331) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Fasting blood glucose ( 31217584) Fasting glucose ( 34074324) Height ( 31562340) Iris color (b* coordinate) ( 30895295) Ischemic stroke ( 26708676) Ischemic stroke (large artery atherosclerosis) ( 26708676) Large artery stroke ( 28265093 24262325) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Late-onset Alzheimer's disease ( 27770636) Loneliness ( 27629369) Male-pattern baldness ( 27182965 22693459 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 31628463) Moderate-to-late spontaneous preterm birth ( 31194736) Monobrow ( 27182965) Moyamoya disease ( 29273593) Myocardial infarction ( 33532862) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30374069) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Peripheral artery disease ( 31285632 26488411) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 29403010 28739976 26390057 27841878 30487518) Reading disability ( 32108986) Reasoning ( 29907492) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Response to lithium treatment in bipolar disorder (continuous phenotype) ( 26806518) Resting-state electroencephalogram vigilance ( 29703947) Retinopathy in non-diabetics ( 23393555) Stroke ( 26089329 22306652) Stroke (ischemic) ( 23041239) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Systolic blood pressure ( 27841878 30487518) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 20848476) Zinc levels ( 26025379)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		30 interacting genes: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 H3C15 H4C16 HDAC1 HDAC3 HDAC4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 NRIP1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SYK TRIM29 USF1 YWHAZ ZBTB16	61 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AC25 H2BC26 H3-4 H3C1 H3C15 H4C16 HDAC4 HDAC5 HDAC9 HECW2 INCENP ISG15 LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBC UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		9734	23468
HPRD ID		05944	05131
Ensembl ID		ENSG00000048052	ENSG00000094916
Uniprot IDs		A0A7P0T8F4 A0A7P0TAB5 A0A9L9PXL9 B7Z3P7 Q9UKV0	P45973 V9HWG0
PDB IDs		8Q9N 8Q9R	3FDT 3I3C 8UXQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Repressor Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Histone Deacetylase Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleus DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Nucleoplasm Transcription Corepressor Binding Chromatin Binding Rhythmic Process Positive Regulation Of RNA Metabolic Process Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process JUN Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process Fc-epsilon Receptor Signaling Pathway MAPK Cascade Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Protein Kinase Binding Chromatin Organization Chromatin Remodeling	Chromatin Organization Chromatin Remodeling Chromosome Nucleus Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Epigenetic Regulation Of Gene Expression Heterochromatin Formation Chromo Shadow Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Heterochromatin DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein-DNA Complex Assembly Chromosome Segregation Regulation Of Macromolecule Biosynthetic Process Euchromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Assembly Chromatin MIS12/MIND Type Complex Chromosome Organization Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Chromosome, Centromeric Region Chromosome, Telomeric Region DNA Damage Response Histone Deacetylase Activity, Hydrolytic Mechanism Transcription Corepressor Activity Histone H2AK127 Ubiquitin Ligase Activity
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