HDAC9

Name	histone deacetylase 9
Structure
Interactors	30 interactors: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 H3C15 H4C16 HDAC1 HDAC3 HDAC4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 NRIP1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SYK TRIM29 USF1 YWHAZ ZBTB16
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Histone Methyltransferase Complex
	Molecular Function	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Histone H3K14 Deacetylase Activity, Hydrolytic Mechanism Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone H4K16 Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Chromatin Organization Inflammatory Response Heart Development Negative Regulation Of Macromolecule Biosynthetic Process B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Cholesterol Homeostasis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway
Drugs	Valproic acid Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
GWAS	Abdominal aortic calcification levels ( 31659325 ) Appendicular lean mass ( 33097823 ) Brain morphology (MOSTest) ( 32665545 ) Cerebral amyloid angiopathy ( 25188341 ) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681 ) Coronary artery disease ( 32469254 26343387 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary artery disease or large artery stroke ( 24262325 ) Cortical surface area (visual PC2) ( 32198502 ) Cortical volume ( 32963231 ) Depressive symptom (fatigue) (ordinal trait) ( 31530331 ) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383 ) Fasting blood glucose ( 31217584 ) Fasting glucose ( 34074324 ) Height ( 31562340 ) Iris color (b* coordinate) ( 30895295 ) Ischemic stroke ( 26708676 ) Ischemic stroke (large artery atherosclerosis) ( 26708676 ) Large artery stroke ( 28265093 24262325 ) Large artery stroke (CCS and TOAST classification) ( 32047268 ) Large artery stroke (CCS or TOAST classification) ( 32047268 ) Large artery stroke (CCSp classification)j ( 32047268 ) Large artery stroke (TOAST classification) ( 32047268 ) Late-onset Alzheimer's disease ( 27770636 ) Loneliness ( 27629369 ) Male-pattern baldness ( 27182965 22693459 28196072 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Metabolite levels ( 31628463 ) Moderate-to-late spontaneous preterm birth ( 31194736 ) Monobrow ( 27182965 ) Moyamoya disease ( 29273593 ) Myocardial infarction ( 33532862 ) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411 ) Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411 ) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Osteoarthritis (hip) ( 30374069 ) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912 ) Peripheral artery disease ( 31285632 26488411 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Pulse pressure ( 29403010 28739976 26390057 27841878 30487518 ) Reading disability ( 32108986 ) Reasoning ( 29907492 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 ) Response to lithium treatment in bipolar disorder (continuous phenotype) ( 26806518 ) Resting-state electroencephalogram vigilance ( 29703947 ) Retinopathy in non-diabetics ( 23393555 ) Stroke ( 26089329 22306652 ) Stroke (ischemic) ( 23041239 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic juvenile idiopathic arthritis ( 27927641 ) Systolic blood pressure ( 27841878 30487518 ) Type 2 diabetes (age of onset) ( 28060188 ) Ulcerative colitis ( 20848476 ) Zinc levels ( 26025379 )
Entrez ID	9734
HPRD ID	05944
Ensembl ID	ENSG00000048052
Uniprot IDs	A0A7P0T8F4 A0A7P0TAB5 A0A9L9PXL9 B7Z3P7 Q9UKV0
PDB IDs	8Q9N 8Q9R
GO Terms Enriched among Interactors ?	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Repressor Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Histone Deacetylase Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleus DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Nucleoplasm Transcription Corepressor Binding Chromatin Binding Rhythmic Process Positive Regulation Of RNA Metabolic Process Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process JUN Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process Fc-epsilon Receptor Signaling Pathway MAPK Cascade Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Protein Kinase Binding Chromatin Organization Chromatin Remodeling