HDAC9 and USF1

Number of citations of the paper that reports this interaction (PMID 19303849)
39

Data Source:
HPRD (in vivo)

		HDAC9	USF1
Gene Name		histone deacetylase 9	upstream transcription factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Histone Methyltransferase Complex	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	Double-stranded DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Kinase Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Peptidyl-lysine Deacetylation B Cell Activation Negative Regulation Of Transcription, DNA-templated Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Hypoxia Glucose Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Response To UV Late Viral Transcription Cellular Response To Insulin Stimulus Glucose Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Carbon Catabolite Regulation Of Transcription Negative Regulation Of Fibrinolysis Lipid Homeostasis
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs		Valproic Acid
Diseases
GWAS		Male-pattern baldness ( 22693459) Obesity-related traits ( 23251661) Retinopathy in non-diabetics ( 23393555) Stroke ( 22306652) Stroke (ischemic) ( 23041239) Ulcerative colitis ( 20848476)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		31 interactors: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 HDAC1 HDAC3 HDAC4 HIST2H3A HIST4H4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 NRIP1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SUV39H1 SYK TRIM29 USF1 YWHAZ ZBTB16	13 interactors: APP ESR1 FOS FOSL1 GTF2I HDAC9 NFYA PPRC1 PRKDC TCF3 TCFL5 TRAF2 USF2
Entrez ID		9734	7391
HPRD ID		05944	01880
Ensembl ID		ENSG00000048052	ENSG00000158773
Uniprot IDs		B7Z3P7 Q9UKV0	P22415
PDB IDs			1AN4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor 2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Activation Of Innate Immune Response RNA Metabolic Process Regulation Of Histone Deacetylation Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Binding Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stress	Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Immunoglobulin V(D)J Recombination B Cell Lineage Commitment Positive Regulation Of Metabolic Process Cellular Metabolic Process Biosynthetic Process B Cell Differentiation Response To Gravity Reproductive Process Defense Response Organ Development Learning Response To Oxidative Stress B Cell Activation Regulation Of Stem Cell Maintenance V(D)J Recombination Cell Communication Regulation Of Cell Differentiation Response To Hormone Regulation Of Cellular Process Response To Organic Substance Somatic Recombination Of Immunoglobulin Gene Segments Response To Corticosterone
Tagcloud ?		ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1	affective bdnf bisulfite choline dams epigenetically explicate formerly g11 g18 hdac1 id impairments iron methylations modifies neurotrophic pnd pnd15 pnd65 pnd7 postnatal prompt pups repletion revealing reverses span supplementation
Tagcloud (Difference) ?		ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1	affective bdnf bisulfite choline dams epigenetically explicate formerly g11 g18 hdac1 id impairments iron methylations modifies neurotrophic pnd pnd15 pnd65 pnd7 postnatal prompt pups repletion revealing reverses span supplementation
Tagcloud (Intersection) ?