SYN1 and BIN1

Number of citations of the paper that reports this interaction (PMID 10899172)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		SYN1	BIN1
Gene Name		synapsin I	bridging integrator 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Cytosol Synaptic Vesicle Cell Junction Dendrite	Nucleus Cytoplasm Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon I Band Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube
	Molecular Function	Actin Binding Catalytic Activity Transporter Activity Protein Binding ATP Binding Protein Kinase Binding Calcium-dependent Protein Binding	Protein Binding Protein Complex Binding Identical Protein Binding Protein Heterodimerization Activity Tau Protein Binding GTPase Binding RNA Polymerase Binding
	Biological Process	Synaptic Transmission Neurotransmitter Secretion Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis	Endocytosis Cell Proliferation Viral Process Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Astrocyte Differentiation Lipid Tube Assembly Regulation Of Cell Cycle Arrest
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Alzheimer's disease ( 22832961 21460840 21627779 22005930) Alzheimer's disease (late onset) ( 21460841 21390209)
Protein-Protein Interactions		30 interactors: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 S100A1 SH3GL2 SNCA SPTAN1 SRC SYN2 SYN3 VIM	36 interactors: ABL1 AMPH AP2A1 AP2A2 APP ASAP2 ATXN2 CUX1 DLGAP4 DNM1 DNM2 FBP1 ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC XRCC4 ZBTB3
Entrez ID		6853	274
HPRD ID		02433	03150
Ensembl ID		ENSG00000008056	ENSG00000136717
Uniprot IDs		P17600	B7Z6Y2 O00499 Q9BTH3
PDB IDs			1MUZ 1MV0 1MV3 2FIC 2RMY 2RND
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Endocytosis Positive Regulation Of Metabolic Process Regulation Of Cellular Component Organization Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Chemotaxis Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Axonogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Locomotion Cell Differentiation Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Protein Phosphorylation Neuron Projection Morphogenesis Regulation Of Signaling Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Neurotrophin Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Metabolic Process	Regulation Of Signaling Endocytosis Generation Of Neurons Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Regulation Of ERBB Signaling Pathway Neurogenesis Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Signal Transduction Axon Guidance Neuron Differentiation Neuron Development Nervous System Development Vesicle-mediated Transport Chemotaxis Signaling Neuron Projection Development Locomotion Cell Communication Anatomical Structure Morphogenesis Cell Morphogenesis Axonogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Negative Regulation Of Signaling Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Cell Development Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Blood Coagulation
Tagcloud ?		anthropometry bf bifidobacterium bifidogenic breastfed breastfeeding carbohydrates closer colonized digestive faecal fermentable formula formulas infant inulin microbiota nct00808756 newborns oligofructose orafti prebiotic softer sterile stool stools supplemented synergy1 try	a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40
Tagcloud (Difference) ?		anthropometry bf bifidobacterium bifidogenic breastfed breastfeeding carbohydrates closer colonized digestive faecal fermentable formula formulas infant inulin microbiota nct00808756 newborns oligofructose orafti prebiotic softer sterile stool stools supplemented synergy1 try	a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40
Tagcloud (Intersection) ?