SYN1 and CAMK1

Number of citations: 0 (PubMedID 12237306)
Data Source: HPRD (in vitro)

		SYN1	CAMK1
Name		synapsin I	calcium/calmodulin dependent protein kinase I
Structure		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Golgi Apparatus Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Cell Body Synapse Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Presynapse Extrinsic Component Of Synaptic Vesicle Membrane	Nucleus Cytoplasm Cytosol Postsynaptic Density
	Molecular Function	Actin Binding Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding Cytoskeletal Protein-membrane Anchor Activity	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis	Protein Phosphorylation Nucleocytoplasmic Transport Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Intracellular Signal Transduction Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Sensory processing of sound by inner hair cells of the cochlea	Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Adenosine 5'-[gamma-thio]triphosphate	Fostamatinib
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM	23 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 HUNK IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1
Entrez ID		6853	8536
HPRD ID		02433	05412
Ensembl ID		ENSG00000008056	ENSG00000134072
Uniprot IDs		P17600	B0YIY3 Q14012
PDB IDs		Not available	4FG7 4FG8 4FG9 4FGB
GO Terms Enriched among Interactors		Cytosol Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Biological Quality Regulation Of Organelle Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Postsynaptic Density Regulation Of Cellular Localization Presynaptic Endocytosis Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Cytoplasm Regulation Of Protein-containing Complex Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Neurotrophin TRKA Receptor Binding Protein Serine Kinase Activity Protein Kinase Activity Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Component Size Cellular Response To Nutrient Levels Protein Serine/threonine Kinase Activity Glutamatergic Synapse Actin Filament-based Process Cytoskeleton Organization Regulation Of Developmental Process Regulation Of Neuron Projection Development Kinase Activity Regulation Of Innate Immune Response Regulation Of Transport Cell Junction Organization Response To Growth Factor Regulation Of Heart Contraction Positive Regulation Of Protein-containing Complex Assembly	Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cyclin D1-CDK4 Complex Cell Cycle Phase Transition Response To Metal Ion Peptidyl-cysteine S-nitrosylase Activity Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Activity Positive Regulation Of Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Calcium-mediated Signaling Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Autophagy Positive Regulation Of Interleukin-1 Production Kinase Activity Regulation Of Metabolic Process Calcium-dependent Protein Binding Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Response To Lead Ion Calyx Of Held Regulation Of Neurotransmitter Uptake Regulation Of Cell Cycle Process Regulation Of Neuron Apoptotic Process Regulation Of Locomotion Nucleus Regulation Of Cell Cycle Calcium/calmodulin-dependent Protein Kinase Activity Protein-containing Complex Regulation Of Interleukin-1 Production Nucleoplasm Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Mitotic Cell Cycle