SYN1 and BLM

Number of citations of the paper that reports this interaction (PMID 15829507)
41

Data Source:
BioGRID (two hybrid)

		SYN1	BLM
Gene Name		synapsin I	Bloom syndrome, RecQ helicase-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Cytosol Synaptic Vesicle Cell Junction Dendrite	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Male Germ Cell Nucleus Nucleus Replication Fork Nucleolus Cytoplasm Nuclear Matrix PML Body Pronucleus
	Molecular Function	Actin Binding Catalytic Activity Transporter Activity Protein Binding ATP Binding Protein Kinase Binding Calcium-dependent Protein Binding	Bubble DNA Binding P53 Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Four-way Junction Helicase Activity ATPase Activity Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding
	Biological Process	Synaptic Transmission Neurotransmitter Secretion Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Strand Renaturation DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To X-ray Replication Fork Processing DNA Duplex Unwinding Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Recombination Negative Regulation Of Mitotic Recombination Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Replication Fork Protection Regulation Of Binding Protein Oligomerization Negative Regulation Of Cell Division Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses	Meiotic recombination
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 S100A1 SH3GL2 SNCA SPTAN1 SRC SYN2 SYN3 VIM	33 interactors: ATM ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 FANCD2 FEN1 MCRS1 MIB1 MLH1 MX1 PSMD3 RAD51 RAD51D RNF8 RPA1 SMC1A SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TOPBP1 TP53 TP53BP1 TRIM49 UBE2I UPF2 WRN
Entrez ID		6853	641
HPRD ID		02433	05211
Ensembl ID		ENSG00000008056	ENSG00000197299
Uniprot IDs		P17600	P54132
PDB IDs			2KV2 2RRD
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Endocytosis Positive Regulation Of Metabolic Process Regulation Of Cellular Component Organization Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Chemotaxis Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Axonogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Locomotion Cell Differentiation Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Protein Phosphorylation Neuron Projection Morphogenesis Regulation Of Signaling Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Neurotrophin Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Metabolic Process	Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Repair Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Recombination Cell Cycle Response To Stress Cell Cycle Process Organelle Organization Response To Radiation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Aging Telomere Maintenance Nitrogen Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of DNA Metabolic Process Meiotic Nuclear Division Meiotic Cell Cycle Cell Cycle Checkpoint Response To Abiotic Stimulus Replicative Senescence Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Cellular Response To Ionizing Radiation Regulation Of DNA Replication Response To UV Cellular Response To Radiation Mitotic Cell Cycle Protein Sumoylation Metabolic Process DNA Damage Checkpoint DNA Conformation Change Response To Stimulus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Aging Regulation Of Cell Cycle Process
Tagcloud ?		anthropometry bf bifidobacterium bifidogenic breastfed breastfeeding carbohydrates closer colonized digestive faecal fermentable formula formulas infant inulin microbiota nct00808756 newborns oligofructose orafti prebiotic softer sterile stool stools supplemented synergy1 try	bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol
Tagcloud (Difference) ?		anthropometry bf bifidobacterium bifidogenic breastfed breastfeeding carbohydrates closer colonized digestive faecal fermentable formula formulas infant inulin microbiota nct00808756 newborns oligofructose orafti prebiotic softer sterile stool stools supplemented synergy1 try	bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol
Tagcloud (Intersection) ?