SYN1 and SYN2

Number of citations of the paper that reports this interaction (PMID 10358015)
11

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SYN1	SYN2
Gene Name		synapsin I	synapsin II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Cytosol Synaptic Vesicle Cell Junction Dendrite	Cell Junction Synaptic Vesicle Membrane Synapse
	Molecular Function	Actin Binding Catalytic Activity Transporter Activity Protein Binding ATP Binding Protein Kinase Binding Calcium-dependent Protein Binding	Catalytic Activity ATP Binding
	Biological Process	Synaptic Transmission Neurotransmitter Secretion Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis	Synaptic Transmission Neurotransmitter Secretion Metabolic Process
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Fasting insulin-related traits (interaction with BMI) ( 22581228) Platelet counts ( 22139419) Type 2 diabetes ( 18372903)
Protein-Protein Interactions		30 interactors: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 S100A1 SH3GL2 SNCA SPTAN1 SRC SYN2 SYN3 VIM	6 interactors: NOS1AP PRKACA SYN1 SYN3 YWHAE YWHAZ
Entrez ID		6853	6854
HPRD ID		02433	02857
Ensembl ID		ENSG00000008056
Uniprot IDs		P17600	Q86VA8
PDB IDs
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Endocytosis Positive Regulation Of Metabolic Process Regulation Of Cellular Component Organization Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Chemotaxis Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Axonogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Locomotion Cell Differentiation Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Protein Phosphorylation Neuron Projection Morphogenesis Regulation Of Signaling Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Neurotrophin Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Metabolic Process	Regulation Of Heart Rate Regulation Of Heart Rate By Chemical Signal Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Signaling Regulation Of Heart Contraction Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Membrane Repolarization Positive Regulation Of Transport Positive Regulation Of Intracellular Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell-cell Signaling Regulation Of Potassium Ion Transmembrane Transport Regulation Of Synaptic Transmission Regulation Of Cellular Localization Cardiac Conduction Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transport Regulation Of Ion Transmembrane Transport Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Cation Channel Activity Secretion By Cell Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Regulation Of Cell Death Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Dense Core Granule Biogenesis Neurotransmitter Secretion Regulation Of Ion Transport Secretion G2/M Transition Of Mitotic Cell Cycle Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Heart Rate By Hormone Histone H3-T6 Phosphorylation Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Neurotransmitter Levels Establishment Of Localization In Cell Regulation Of Protein Localization Neurotransmitter Transport Membrane Organization Regulation Of Generation Of L-type Calcium Current Golgi Reassembly
Tagcloud ?		anthropometry bf bifidobacterium bifidogenic breastfed breastfeeding carbohydrates closer colonized digestive faecal fermentable formula formulas infant inulin microbiota nct00808756 newborns oligofructose orafti prebiotic softer sterile stool stools supplemented synergy1 try	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		anthropometry bf bifidobacterium bifidogenic breastfed breastfeeding carbohydrates closer colonized digestive faecal fermentable formula formulas infant inulin microbiota nct00808756 newborns oligofructose orafti prebiotic softer sterile stool stools supplemented synergy1 try	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?