AQR and WDR77

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		AQR	WDR77
Gene Name		aquarius intron-binding spliceosomal factor	WD repeat domain 77
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	MRNA Splicing, Via Spliceosome	Spliceosomal SnRNP Assembly Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Gene Expression NcRNA Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways			Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: PQBP1 RBM22 RBM4 WDR77 WDR83	35 interactors: AQR BAG2 COPRS CTDP1 GPKOW HIST2H2AB HNRNPM LSM3 NKX3-1 PCBP2 PPIL1 PPP1R8 PQBP1 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZNF207
Entrez ID		9716	79084
HPRD ID		12468	14387
Ensembl ID		ENSG00000021776	ENSG00000116455
Uniprot IDs		O60306	B4DP38 Q9BQA1
PDB IDs			4GQB
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Nitrogen Compound Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development IRES-dependent Translational Initiation Cap-independent Translational Initiation Circadian Regulation Of Translation Negative Regulation Of Translation In Response To Stress Ribonucleoprotein Complex Biogenesis Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Cytoplasmic Translational Initiation Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Alternative MRNA Splicing, Via Spliceosome Regulation Of Intracellular Transport Cytoplasmic Translation Stress Granule Assembly Regulation Of Translation In Response To Stress MRNA Cis Splicing, Via Spliceosome Epithelial Cell Differentiation Involved In Prostate Gland Development Negative Regulation Of Translational Initiation Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Entrainment Of Circadian Clock By Photoperiod Regulation Of RNA Metabolic Process Photoperiodism Entrainment Of Circadian Clock Response To Arsenic-containing Substance Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Import Into Nucleus, Translocation Cellular Macromolecular Complex Assembly Positive Regulation Of RNA Splicing Gene Silencing By MiRNA Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Posttranscriptional Gene Silencing Spliceosomal SnRNP Assembly Glandular Epithelial Cell Differentiation Cellular Response To Drug Gene Silencing By RNA	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process Gene Expression RNA Metabolic Process Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Spliceosomal Complex Assembly Transcription, DNA-templated Histone MRNA Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Cellular Component Assembly NcRNA Metabolic Process Termination Of RNA Polymerase II Transcription DNA-templated Transcription, Termination MRNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA 3'-end Processing MRNA 3'-splice Site Recognition Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Histone Methylation Regulation Of RNA Metabolic Process MRNA Splice Site Selection Biosynthetic Process Histone H4-R3 Methylation Protein Methylation Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Alternative MRNA Splicing, Via Spliceosome Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of RNA Splicing Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		adaptor adf afd arr arrestin asi balanced caenorhabditis chemosensory consequences deleterious elegans excessive gpcr gpcrs homeostasis immunity innate insufficient killing longevity microbial organismal pathogen played pqr thermosensory unfolded urx	androgen androgens ar ara70 ara70alpha ara70beta art benign coactivator coactivators corepressor cytoplasmic dysregulation ele1 exhibiting inhibitions internally luciferase mep50 ncoa4 p44 pca promotion spliced suppressive switch switches tblr1 versions
Tagcloud (Difference) ?		adaptor adf afd arr arrestin asi balanced caenorhabditis chemosensory consequences deleterious elegans excessive gpcr gpcrs homeostasis immunity innate insufficient killing longevity microbial organismal pathogen played pqr thermosensory unfolded urx	androgen androgens ar ara70 ara70alpha ara70beta art benign coactivator coactivators corepressor cytoplasmic dysregulation ele1 exhibiting inhibitions internally luciferase mep50 ncoa4 p44 pca promotion spliced suppressive switch switches tblr1 versions
Tagcloud (Intersection) ?