AQR and MIR25

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		AQR	MIR25
Description		aquarius intron-binding spliceosomal factor	microRNA 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Extracellular Space RISC Complex
	Molecular Function	Nucleotide Binding RNA Binding RNA Helicase Activity Single-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Interacting Genes		40 interacting genes: MIR1-1 MIR106A MIR106B MIR107 MIR128-2 MIR145 MIR15B MIR199A2 MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR214 MIR221 MIR222 MIR25 MIR29A MIR31 MIR34A MIR34B MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7G MIRLET7I PQBP1 RBM22 RBM4 WDR77	100 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CPSF6 CPSF7 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 ELAC1 EPRS1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PATL1 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA PURB QARS1 RARS1 RBFOX2 RBM14 RBM17 RBM4 RBM45 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM56 TRIM71 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3
Entrez ID		9716	407014
HPRD ID		12468
Ensembl ID		ENSG00000021776	ENSG00000207547
Uniprot IDs		O60306
PDB IDs		4PJ3 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7ABI 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Cytokine Production Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Development Negative Regulation Of Developmental Process Regulation Of Muscle Cell Differentiation Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signal Transduction	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleoplasm Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Regulation Of Translation MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Metabolic Process TRNA Aminoacylation Ligase Activity MRNA Stabilization Negative Regulation Of Metabolic Process P-body
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