CLINT1 and AP2A1

Number of citations of the paper that reports this interaction (PubMedID 12429846)
46

Data Source:
HPRD (in vitro)

		CLINT1	AP2A1
Description		clathrin interactor 1	adaptor related protein complex 2 subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Adaptor Complex Clathrin-coated Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Protein-containing Complex Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Cadherin Binding	Protein Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Endocytosis Clathrin Coat Assembly	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways		Golgi Associated Vesicle Biogenesis	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Appendicular lean mass ( 33097823)
Interacting Genes		14 interacting genes: AP1G1 AP2A1 AP2B1 CALM1 CEBPA CLTC DNM1 EPS15 GDPD5 GGA1 GGA2 GGA3 JUN YWHAG	29 interacting genes: AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DSCAM DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 PLK2 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC
Entrez ID		9685	160
HPRD ID		06273	03016
Ensembl ID		ENSG00000113282	ENSG00000196961
Uniprot IDs		A0A0S2Z4Y4 A0A0S2Z5H3 Q14677	O95782
PDB IDs		1XGW 2QY7 2V8S
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Clathrin Coat Assembly Clathrin-coated Vesicle Vesicle-mediated Transport In Synapse Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Presynaptic Endocytosis Postsynaptic Endocytic Zone Cytosolic Transport Golgi Vesicle Transport AP-2 Adaptor Complex Intracellular Protein Transport Establishment Of Protein Localization Receptor-mediated Endocytosis Import Into Cell Trans-Golgi Network Receptor Internalization Clathrin Adaptor Activity Endolysosome Membrane Establishment Of Localization In Cell Protein Transport Clathrin-coated Endocytic Vesicle Intracellular Transport Ubiquitin Binding Intracellular Protein Localization Membrane Coat Protein Localization To Cell Surface Clathrin-dependent Endocytosis Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Negative Regulation Of Hyaluronan Biosynthetic Process Synaptic Vesicle Endocytosis Cellular Localization Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Of Coated Pit Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Protein-containing Complex Early Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Clathrin Adaptor Complex Endosomal Transport Golgi To Endosome Transport Small GTPase Binding Phosphatidylinositol Binding	Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Clathrin Coat Assembly Clathrin-coated Pit Clathrin-coated Vesicle Phospholipid Binding Receptor Internalization Clathrin Coat Of Coated Pit Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Endosome Protein-containing Complex Assembly Phosphatidylinositol-4,5-bisphosphate Binding Ciliary Pocket Membrane Protein-containing Complex Organization Receptor-mediated Endocytosis Plasma Membrane Regulation Of Endocytosis Synaptic Vesicle Endocytosis Presynapse Presynaptic Endocytosis Regulation Of Amyloid-beta Formation Tau Protein Binding Cytoplasmic Vesicle Postsynaptic Neurotransmitter Receptor Internalization Endomembrane System Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Clathrin Vesicle Coat Ciliary Membrane Establishment Of Localization In Cell AP-2 Adaptor Complex Cytosol Establishment Of Protein Localization Vesicle Organization Cadherin Binding SNARE Binding Lipid Binding Endocytic Vesicle Membrane Cellular Component Assembly Glutamatergic Synapse Protein Transport Regulation Of Amide Metabolic Process Synaptic Vesicle Priming Membrane Clathrin Adaptor Activity Calcium Ion Sensor Activity Organelle Organization
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