TGS1 and EED

Number of citations of the paper that reports this interaction (PMID 12943661)
7

Data Source:
BioGRID (pull down, two hybrid)
HPRD (two hybrid, in vitro)

		TGS1	EED
Gene Name		trimethylguanosine synthase 1	embryonic ectoderm development
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Small Nuclear Ribonucleoprotein Complex	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus
	Molecular Function	Protein Binding RNA Trimethylguanosine Synthase Activity	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding
	Biological Process	Spliceosomal SnRNP Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated 7-methylguanosine RNA Capping Gene Expression Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process 7-methylguanosine Cap Hypermethylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Ribonucleoprotein Complex Import Into Nucleus	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of non-coding RNA REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway snRNP Assembly Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		6 interactors: COIL CREBBP EED EP300 HNF4A NCOA6	38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42
Entrez ID		96764	8726
HPRD ID		07567	09343
Ensembl ID		ENSG00000137574	ENSG00000074266
Uniprot IDs		Q96RS0	E9PJK2 O75530
PDB IDs		3EGI 3GDH	3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia RNA Biosynthetic Process N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress RNA Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Metabolic Process Gene Expression Cellular Response To Heat Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Type I Interferon Production Chromatin Modification Cellular Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Regulation Of Transcription, DNA-templated Histone H2B Acetylation Regulation Of Nucleic Acid-templated Transcription Cellular Response To Oxygen Levels Regulation Of RNA Biosynthetic Process Response To Heat Histone Acetylation Regulation Of RNA Metabolic Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Chromatin Organization Internal Protein Amino Acid Acetylation Nucleobase-containing Compound Metabolic Process Protein Acetylation Notch Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process
Tagcloud ?		accumulate accumulates billion dormancy dosr drastic droplet droplets fatty filled granuloma hspx hypoxic icl1 imports incorporates inside isoniazid latently lipid lipy loaded mtb radiolabeled sequestered tag taqman triacylglycerol utilizes	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?		accumulate accumulates billion dormancy dosr drastic droplet droplets fatty filled granuloma hspx hypoxic icl1 imports incorporates inside isoniazid latently lipid lipy loaded mtb radiolabeled sequestered tag taqman triacylglycerol utilizes	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?