TGS1 and ZNF76

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGS1	ZNF76
Description		trimethylguanosine synthase 1	zinc finger protein 76
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Small Nuclear Ribonucleoprotein Complex	Nucleus
	Molecular Function	Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity RNA Cap Trimethylguanosine Synthase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Spliceosomal SnRNP Assembly RNA Methylation Ribonucleoprotein Complex Biogenesis Methylation 7-methylguanosine Cap Hypermethylation	Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase II
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression snRNP Assembly PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Height ( 18391951) Serum thyroid-stimulating hormone levels ( 24852370)	Height ( 18391951 25282103 31562340) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ANKRD28 CFTR COIL CREBBP EED EP300 HNF4A NCOA6 NOXA1 RNF10 ZNF76	93 interacting genes: ACAT2 ALOXE3 ANKRD37 ANTKMT ATP5PO BLZF1 BOLA2 BOLA2B C10orf55 C22orf15 C3orf36 CCDC33 CEACAM6 CEP76 CSN3 DDIT4L DISC1 ENKD1 EP300 EXOSC1 FAM228A FAM90A1 FCRL4 FNDC8 FSD2 GIMAP6 GRAPL HDAC1 HOMEZ HUNK IKZF3 KCTD9 KLF15 KPNA3 KRT40 KRT75 L3MBTL3 LAP3 LETM1 LHX3 LHX4 LHX6 LIN37 LIN54 LMO1 MAGEA6 MBD3L1 MBD5 MED19 MFAP1 MORN3 MRPL12 MTFR1L MTUS2 MYL10 NEDD9 NRIP2 PIAS1 PMPCA POGZ PRKAR1B RAB3IP RALY REL RNF214 RPRD1A RPS21 SCNM1 SLAIN1 SMAD1 SNAI2 SPANXN3 SPATA8 SPMIP10 STMN3 TASOR2 TBC1D22B TBP TEKT5 TGS1 TNNI1 USP54 USP6 USP7 VXN WDR83 YPEL3 ZC2HC1C ZC4H2 ZMYM6 ZNF420 ZNF526 ZNF623
Entrez ID		96764	7629
HPRD ID		07567	01929
Ensembl ID		ENSG00000137574	ENSG00000065029
Uniprot IDs		Q96RS0	P36508
PDB IDs		3EGI 3GDH
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Chromatin Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleus Tau Protein Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Transcription Regulator Complex Rhythmic Process Transcription Coactivator Binding Protein Destabilization Positive Regulation Of RNA Metabolic Process Canonical NF-kappaB Signal Transduction Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Regulation Of Ornithine Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Activity Damaged DNA Binding P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Anion Channel Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H2B Acetyltransferase Activity	Protein Binding Medial Motor Column Neuron Differentiation
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