TGS1 and COIL

Number of citations of the paper that reports this interaction (PubMedID 34079125)
0

Data Source:
BioGRID (proximity labelling technology, two hybrid)
HPRD (two hybrid)

		TGS1	COIL
Description		trimethylguanosine synthase 1	coilin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Small Nuclear Ribonucleoprotein Complex	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Nuclear Body
	Molecular Function	Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity RNA Cap Trimethylguanosine Synthase Activity	Protein Binding U1 SnRNA Binding U2 SnRNA Binding Identical Protein Binding
	Biological Process	Spliceosomal SnRNP Assembly RNA Methylation Ribonucleoprotein Complex Biogenesis Methylation 7-methylguanosine Cap Hypermethylation	Spliceosomal SnRNP Assembly
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression snRNP Assembly PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Height ( 18391951) Serum thyroid-stimulating hormone levels ( 24852370)	Height ( 18391951)
Interacting Genes		11 interacting genes: ANKRD28 CFTR COIL CREBBP EED EP300 HNF4A NCOA6 NOXA1 RNF10 ZNF76	84 interacting genes: ACTN1 ACTN2 ACTN4 ADAMTS12 APP ARMCX1 ATXN1 ATXN1L BYSL C1QBP C9orf72 CCDC136 CCDC159 CCDC57 CCNE1 CDC23 CDK2 CEP70 CEP76 CSNK2B CYB5R2 DHX16 DNAJA3 DRG1 DYNC2I2 ELOA2 FGF12 FHL5 FXR1 FXR2 GCC1 HSF2BP KALRN KAZN KDM1A KLC2 KLC4 KLHL42 KLHL8 KPNA3 LNX1 MAD1L1 MCRS1 MYO15B MYO5B NFU1 NIF3L1 NKAPD1 NOLC1 NTAQ1 NUDT18 OGT PDE4D PDLIM5 PIAS4 PICK1 PLEKHG4 PLOD3 POLR2L POLR3C PREPL PRMT1 PRMT8 PSMA1 PSME3 PTS SART3 SCYL1 SMN1 SNRPB SNRPF SNX6 SPANXN2 SRPK2 TAF9 TCAF1 TFCP2 TGS1 TSPYL2 XRCC5 XRCC6 ZBTB25 ZCCHC10 ZNF277
Entrez ID		96764	8161
HPRD ID		07567	02605
Ensembl ID		ENSG00000137574	ENSG00000121058
Uniprot IDs		Q96RS0	P38432
PDB IDs		3EGI 3GDH
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Chromatin Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleus Tau Protein Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Transcription Regulator Complex Rhythmic Process Transcription Coactivator Binding Protein Destabilization Positive Regulation Of RNA Metabolic Process Canonical NF-kappaB Signal Transduction Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Regulation Of Ornithine Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Activity Damaged DNA Binding P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Anion Channel Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H2B Acetyltransferase Activity	Cytoplasm Cytosol Nucleoplasm Macromolecule Metabolic Process Nucleic Acid Metabolic Process Spliceosomal SnRNP Assembly Nucleus Cellular Component Assembly Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation Cajal Body Protein Binding Methylosome RNA Metabolic Process Transmembrane Transporter Binding Cytoskeleton Z Disc Pseudopodium Negative Regulation Of DNA Metabolic Process Cyclin E1-CDK2 Complex DNA End Binding Ku70:Ku80 Complex SMN-Sm Protein Complex Small Nuclear Ribonucleoprotein Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Spliceosomal Complex Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Postsynapse Telomere Maintenance POZ Domain Binding Nucleolus Main Axon DNA-dependent Protein Kinase Complex Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Regulation Of RNA Metabolic Process Macromolecule Methylation DNA-templated Transcription Identical Protein Binding Regulation Of Long-term Neuronal Synaptic Plasticity Protein Modification Process Platelet Alpha Granule Lumen Protein-containing Complex Assembly Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Telomeric DNA Binding Cellular Response To Gamma Radiation RNA Splicing Telomere Organization
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