SH3PXD2A and KHDRBS1

Number of citations of the paper that reports this interaction (PubMedID 22745667)
76

Data Source:
BioGRID (unspecified method)

		SH3PXD2A	KHDRBS1
Description		SH3 and PX domains 2A	KH RNA binding domain containing, signal transduction associated 1
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GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Cell Projection Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Grb2-Sos Complex
	Molecular Function	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Domain Specific Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein-containing Complex Binding Molecular Function Inhibitor Activity Protein Tyrosine Kinase Binding
	Biological Process	In Utero Embryonic Development Superoxide Metabolic Process Superoxide Anion Generation Reactive Oxygen Species Metabolic Process Osteoclast Fusion	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Cell Surface Receptor Signaling Pathway Spermatogenesis Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway Regulation Of Cell Cycle
Pathways		Invadopodia formation CDC42 GTPase cycle	PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS		Atrial fibrillation ( 33990960 29892015 28416818 28416822 29290336) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Manganese levels ( 26025379) Periventricular white matter hyperintensities ( 32517579) PR interval ( 32439900 30046033) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314) Telomere length ( 33941849) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Body mass index ( 26426971)
Interacting Genes		7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL	116 interacting genes: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK CBL CD2AP CDC42 CDK1 CEBPA CIRBP CLK1 CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 DSCAM EFEMP1 EMG1 FGR FNBP4 FRK FXR1 FXR2 FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITPRID2 ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OGT OSTF1 PACSIN1 PALS2 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SHANK3 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SRPK2 STAT3 STUB1 TBL1X TJP1 TSPOAP1 TUBB3 UBA52 UBASH3B UBC USP7 VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6
Entrez ID		9644	10657
HPRD ID		10228	03926
Ensembl ID		ENSG00000107957	ENSG00000121774
Uniprot IDs		B3KPL1 B7Z9L8 Q5TCZ1	Q07666
PDB IDs		2DNU 2EGA 2EGC 2EKH	2XA6 3QHE 7Z89 7Z8A 7Z9A 7Z9B 7ZAB 7ZAC 7ZAF 7ZAM
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activator Activity SH2 Domain Binding SH3 Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Podosome Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Immune System Process Regulation Of ERBB Signaling Pathway Caveola Cellular Response To Transforming Growth Factor Beta Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Response To Transforming Growth Factor Beta Negative Regulation Of Cell-substrate Adhesion Grb2-Sos Complex Anchoring Junction Immune Response-regulating Signaling Pathway Focal Adhesion Activation Of Immune Response Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Cellular Component Organization Protein Autophosphorylation Regulation Of Cell-matrix Adhesion Retinal Cell Programmed Cell Death Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Cytoplasmic Vesicle Lumen Negative Regulation Of Cytoskeleton Organization Integrin Binding Cellular Response To Progesterone Stimulus Negative Regulation Of Receptor Binding Response To Hypobaric Hypoxia Negative Regulation Of Supramolecular Fiber Organization Cell-substrate Adhesion	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Cytoplasm Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell-cell Junction Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway SH3 Domain Binding Protein Binding Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signal Transduction T Cell Receptor Signaling Pathway T Cell Costimulation Regulation Of Endocytosis Fc-gamma Receptor Signaling Pathway Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphorylation Regulation Of Transport Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Developmental Process Regulation Of Immune Response Immune System Process Ionotropic Glutamate Receptor Binding Endocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ephrin Receptor Signaling Pathway
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