SH3PXD2A

Description		SH3 and PX domains 2A
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GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Cell Projection Anchoring Junction
	Molecular Function	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	In Utero Embryonic Development Superoxide Metabolic Process Superoxide Anion Generation Reactive Oxygen Species Metabolic Process Osteoclast Fusion
Pathways		Invadopodia formation CDC42 GTPase cycle
Drugs
Diseases
GWAS		Atrial fibrillation ( 33990960 29892015 28416818 28416822 29290336) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Manganese levels ( 26025379) Periventricular white matter hyperintensities ( 32517579) PR interval ( 32439900 30046033) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314) Telomere length ( 33941849) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL
Entrez ID		9644
HPRD ID		10228
Ensembl ID		ENSG00000107957
Uniprot IDs		B3KPL1 B7Z9L8 Q5TCZ1
PDB IDs		2DNU 2EGA 2EGC 2EKH
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activator Activity SH2 Domain Binding SH3 Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Podosome Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Immune System Process Regulation Of ERBB Signaling Pathway Caveola Cellular Response To Transforming Growth Factor Beta Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Response To Transforming Growth Factor Beta Negative Regulation Of Cell-substrate Adhesion Grb2-Sos Complex Anchoring Junction Immune Response-regulating Signaling Pathway Focal Adhesion Activation Of Immune Response Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Cellular Component Organization Protein Autophosphorylation Regulation Of Cell-matrix Adhesion Retinal Cell Programmed Cell Death Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Cytoplasmic Vesicle Lumen Negative Regulation Of Cytoskeleton Organization Integrin Binding Cellular Response To Progesterone Stimulus Negative Regulation Of Receptor Binding Response To Hypobaric Hypoxia Negative Regulation Of Supramolecular Fiber Organization Cell-substrate Adhesion
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