SH3PXD2A and PAK2

Number of citations of the paper that reports this interaction (PubMedID 16374509)
24

Data Source:
HPRD (in vitro)

		SH3PXD2A	PAK2
Description		SH3 and PX domains 2A	p21 (RAC1) activated kinase 2
Image
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Cell Projection Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Nuclear Speck Secretory Granule Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Protein Serine Kinase Activity
	Biological Process	In Utero Embryonic Development Superoxide Metabolic Process Superoxide Anion Generation Reactive Oxygen Species Metabolic Process Osteoclast Fusion	Stimulatory C-type Lectin Receptor Signaling Pathway Cardiac Muscle Hypertrophy Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Starvation Cell Migration Adherens Junction Assembly Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Maturation Dendritic Spine Development Bicellular Tight Junction Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Execution Phase Of Apoptosis Regulation Of Actin Filament Organization Protein Localization To Cell-cell Junction Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Invadopodia formation CDC42 GTPase cycle	Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Atrial fibrillation ( 33990960 29892015 28416818 28416822 29290336) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Manganese levels ( 26025379) Periventricular white matter hyperintensities ( 32517579) PR interval ( 32439900 30046033) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314) Telomere length ( 33941849) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Asthma ( 31959851) Atrial fibrillation ( 29892015) Eosinophil count ( 32888494 27863252) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 27863252 32888494) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) White blood cell count ( 27863252 32888494)
Interacting Genes		7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL	54 interacting genes: ABI1 ABI2 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 CEBPA DOCK2 DSCR9 DST EIF4B EIF4G1 EP300 FYN GRB2 H4C6 HCK LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 OGT PACSIN3 PPM1A RAC1 RAF1 RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		9644	5062
HPRD ID		10228	05428
Ensembl ID		ENSG00000107957	ENSG00000180370
Uniprot IDs		B3KPL1 B7Z9L8 Q5TCZ1	A8K5M4 Q13177
PDB IDs		2DNU 2EGA 2EGC 2EKH	3PCS
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activator Activity SH2 Domain Binding SH3 Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Podosome Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Immune System Process Regulation Of ERBB Signaling Pathway Caveola Cellular Response To Transforming Growth Factor Beta Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Response To Transforming Growth Factor Beta Negative Regulation Of Cell-substrate Adhesion Grb2-Sos Complex Anchoring Junction Immune Response-regulating Signaling Pathway Focal Adhesion Activation Of Immune Response Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Cellular Component Organization Protein Autophosphorylation Regulation Of Cell-matrix Adhesion Retinal Cell Programmed Cell Death Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Cytoplasmic Vesicle Lumen Negative Regulation Of Cytoskeleton Organization Integrin Binding Cellular Response To Progesterone Stimulus Negative Regulation Of Receptor Binding Response To Hypobaric Hypoxia Negative Regulation Of Supramolecular Fiber Organization Cell-substrate Adhesion	Regulation Of Cellular Component Organization Cytosol Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Fc-gamma Receptor Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Cytoplasm Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAPK Cascade Focal Adhesion Protein Phosphorylation Ephrin Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Organelle Organization Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Fc Receptor Signaling Pathway Phosphorylation Positive Regulation Of Cytoskeleton Organization Signal Transduction Anchoring Junction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Organelle Organization Cell Surface Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Immune Response-activating Signaling Pathway Actin Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Endocytosis Regulation Of Cell Activation Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis Regulation Of T Cell Activation Ephrin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Supramolecular Fiber Organization Actin Filament-based Process Protein Kinase Activity Lamellipodium
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