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DTX3 and UBE2L3
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
DTX3
UBE2L3
Gene Name
deltex 3, E3 ubiquitin ligase
ubiquitin-conjugating enzyme E2L 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Zinc Ion Binding
Ligase Activity
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Poly(A) RNA Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activator Activity
Biological Process
Notch Signaling Pathway
Protein Ubiquitination
Protein Polyubiquitination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Cell Proliferation
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin-protein Transferase Activity
Protein K11-linked Ubiquitination
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
21383967
)
HDL cholesterol (
20686565
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular volume (
20139978
)
Red blood cell traits (
23222517
)
Systemic lupus erythematosus (
23273568
21408207
19838193
)
Protein-Protein Interactions
25 interactors:
DTX1
DTX2
RNF141
RNF38
TRAF4
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2DNL
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2K
UBE2L3
UBE2L6
UBE2V1
UBE2W
UEVLD
USP1
USP2
USP21
XIAP
ZDHHC17
64 interactors:
ARIH1
ARIH2
ATXN3
BRCA1
CBL
CBLC
CCNB1IP1
CUL9
DTX3
FBXO2
FOS
HACE1
HERC3
HSPA4
HUWE1
ITCH
LIG4
MAPK6
MDM2
MID1
MKRN3
MUL1
NEDD4
NEDD4L
NFKBIA
NR3C1
PARK2
PJA1
POLR2A
PTEN
RAD23A
RBCK1
RBX1
RELA
RNF103
RNF113B
RNF125
RNF144A
RNF144B
RNF19A
RNF2
RNF216
SMAD4
SMAD7
SMURF1
SMURF2
STUB1
TRAF6
TRAF7
TRIM21
TRIM28
TRIM39
TRIP12
UBA1
UBA6
UBA7
UBASH3A
UBC
UBE3A
UBE3C
UBOX5
UBR5
WWP1
WWP2
Entrez ID
196403
7332
HPRD ID
16842
04762
Ensembl ID
ENSG00000178498
ENSG00000185651
Uniprot IDs
Q8N9I9
P68036
PDB IDs
1C4Z
1FBV
3SQV
3SY2
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Cellular Protein Metabolic Process
Protein K11-linked Ubiquitination
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Metabolic Process
Proteolysis
ISG15-protein Conjugation
Protein K63-linked Ubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Metabolic Process
Regulation Of Proteolysis
Regulation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Cellular Response To Stress
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Protein Monoubiquitination
Activation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Innate Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To DNA Damage Stimulus
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Cellular Protein Metabolic Process
Protein Polyubiquitination
Proteolysis
Protein Metabolic Process
Catabolic Process
Cellular Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Protein Ubiquitination
Viral Process
Regulation Of Protein Catabolic Process
Cellular Response To Organic Substance
Protein K63-linked Ubiquitination
Negative Regulation Of Signal Transduction
Protein K48-linked Ubiquitination
Negative Regulation Of Signaling
Protein Monoubiquitination
Cellular Response To Stress
Metabolic Process
Protein Autoubiquitination
Response To Stress
Regulation Of Signal Transduction
Intracellular Receptor Signaling Pathway
Cellular Response To Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Organic Substance
Response To Growth Factor
Regulation Of Protein Metabolic Process
Regulation Of Type I Interferon Production
Regulation Of Signaling
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Cellular Metabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Cytokine Production
Response To Transforming Growth Factor Beta
Cellular Response To DNA Damage Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
DNA Repair
Positive Regulation Of Protein Catabolic Process
Tagcloud
?
2e37a
2e37b
cav
cav2
channel
channels
clathrin
conjugating
conserved
dynamin
inhibiting
interact
internalization
involves
lc1
light
map1b
mechanism
microtubule
prevented
propose
proteasome
proteolytic
q
triggered
ubiquitin
ubiquitination
variants
Tagcloud (Difference)
?
2e37a
2e37b
cav
cav2
channel
channels
clathrin
conjugating
conserved
dynamin
inhibiting
interact
internalization
involves
lc1
light
map1b
mechanism
microtubule
prevented
propose
proteasome
proteolytic
q
triggered
ubiquitin
ubiquitination
variants
Tagcloud (Intersection)
?