DTX3 and NOTCH2

Number of citations of the paper that reports this interaction (PubMedID 31854042)
29

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		DTX3	NOTCH2
Description		deltex E3 ubiquitin ligase 3	notch receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Placenta Development Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Atrioventricular Node Development Pulmonary Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Humoral Immune Response Notch Signaling Pathway Determination Of Left/right Symmetry Nervous System Development Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Hemopoiesis Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Septum Morphogenesis Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Proximal Tubule Development Podocyte Development Glomerular Capillary Formation Hepatocyte Proliferation Liver Morphogenesis Positive Regulation Of MiRNA Transcription Regulation Of Hemopoiesis Cholangiocyte Proliferation Regulation Of Osteoclast Development
Pathways			Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases			Alagille syndrome Hajdu-Cheney syndrome Type II diabetes mellitus
GWAS			Blood protein levels ( 30072576) Hepatocyte growth factor levels ( 25998175) Nevus count or cutaneous melanoma ( 32341527) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34012112 34127860) Type 2 diabetes ( 18372903 30054458 30297969)
Interacting Genes		46 interacting genes: ARF5 BAG3 DTX1 DTX2 EPHB4 EPM2AIP1 FAM90A1 FYN GRB2 MAPK9 NCK2 NFKBID NOTCH2 OSTF1 PARP11 PTK6 RNF141 RNF38 TCEANC TRAF4 TRIP10 UBASH3A UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UEVLD USP1 USP2 USP21 XIAP YES1 ZDHHC17 ZMYND19	31 interacting genes: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SHANK3 SMAD1
Entrez ID		196403	4853
HPRD ID		16842	02606
Ensembl ID		ENSG00000178498	ENSG00000134250
Uniprot IDs		Q8N9I9	Q04721 Q6IQ50
PDB IDs			2OO4 5MWB
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Protein Monoubiquitination Macromolecule Catabolic Process Protein K63-linked Ubiquitination ATP Binding ISG15 Transferase Activity Positive Regulation Of Protein Polyubiquitination Nucleotide Binding ISG15-protein Conjugation Nucleus Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Nucleoplasm Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Cell Surface Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Ephrin Receptor Signaling Pathway UBC13-MMS2 Complex Regulation Of Signal Transduction Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cytosol Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein K63-linked Ubiquitination Protein Binding Protein Catabolic Process	Notch Signaling Pathway Regulation Of Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Notch Binding Mononuclear Cell Differentiation Regulation Of Cell Adhesion Lymphocyte Differentiation Leukocyte Differentiation Marginal Zone B Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Timing Of Cell Differentiation Positive Regulation Of Signaling Lymphocyte Activation Somitogenesis Regulation Of Development, Heterochronic Signal Transduction Segmentation O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Leukocyte Activation Cell Differentiation Pattern Specification Process MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transcription Coactivator Activity Immune System Process Endothelial Cell Fate Specification Compartment Pattern Specification Mature B Cell Differentiation Involved In Immune Response Cell Activation Myoblast Differentiation Regulation Of Cell Population Proliferation Mature B Cell Differentiation Loop Of Henle Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Animal Organ Morphogenesis
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