DTX3 and USP21

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		DTX3	USP21
Description		deltex E3 ubiquitin ligase 3	ubiquitin specific peptidase 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Metal Ion Binding
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Chromatin Organization Proteolysis Protein Deubiquitination Ribosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS
Interacting Genes		46 interacting genes: ARF5 BAG3 DTX1 DTX2 EPHB4 EPM2AIP1 FAM90A1 FYN GRB2 MAPK9 NCK2 NFKBID NOTCH2 OSTF1 PARP11 PTK6 RNF141 RNF38 TCEANC TRAF4 TRIP10 UBASH3A UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UEVLD USP1 USP2 USP21 XIAP YES1 ZDHHC17 ZMYND19	65 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXD1 FOXM1 H2AC18 H2BC3 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RIPK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 YY1 ZNF350
Entrez ID		196403	27005
HPRD ID		16842	05291
Ensembl ID		ENSG00000178498	ENSG00000143258
Uniprot IDs		Q8N9I9	Q9UK80
PDB IDs			2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Protein Monoubiquitination Macromolecule Catabolic Process Protein K63-linked Ubiquitination ATP Binding ISG15 Transferase Activity Positive Regulation Of Protein Polyubiquitination Nucleotide Binding ISG15-protein Conjugation Nucleus Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Nucleoplasm Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Cell Surface Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Ephrin Receptor Signaling Pathway UBC13-MMS2 Complex Regulation Of Signal Transduction Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cytosol Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein K63-linked Ubiquitination Protein Binding Protein Catabolic Process	Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification Process Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Proteolysis Protein Metabolic Process Peptidase Activity Macromolecule Metabolic Process Protein K48-linked Deubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Deubiquitinase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity Ubiquitin Protein Ligase Activity Protein K63-linked Deubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Catabolic Process K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Polyubiquitination Hydrolase Activity Ubiquitin Protein Ligase Binding Monoubiquitinated Protein Deubiquitination Regulation Of Cellular Response To Stress Ubiquitin Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process TOR Signaling Response To Stress Nucleoplasm DeNEDDylase Activity DNA Damage Response Zinc Ion Binding Negative Regulation Of TOR Signaling Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction DNA Repair Regulation Of Telomere Maintenance Positive Regulation Of Autophagy Negative Regulation Of Intracellular Signal Transduction
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