NELFE and VAMP3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NELFE	VAMP3
Gene Name		negative elongation factor complex member E	vesicle-associated membrane protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion NELF Complex	Intracellular Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Integral Component Of Membrane Apical Plasma Membrane Cell Junction Clathrin-coated Vesicle Secretory Granule Clathrin-coated Vesicle Membrane SNARE Complex Neuron Projection Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin-1 Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Biological_process Gene Expression Viral Process Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Positive Regulation Of Receptor Recycling Protein Complex Assembly Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Neurotransmitter Secretion Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Positive Regulation Of Immunoglobulin Secretion Membrane Fusion Mucus Secretion Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Crohn's disease ( 21102463) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		10 interactors: CACTIN CCDC57 MTUS2 NCOR1 NELFB SRPK1 SRPK2 SUMO1 TRIM27 VAMP3	14 interactors: ACAP1 APP BCAP31 BCL2L13 DDB1 IKBKG NELFE SNAP23 STX16 STX2 STX3 STX4 VAMP2 VAMP8
Entrez ID		7936	9341
HPRD ID		01096	04711
Ensembl ID		ENSG00000204356	ENSG00000049245
Uniprot IDs		P18615	Q15836 Q6FGG2 Q9BRV4
PDB IDs		1X5P 2BZ2 2JX2
Enriched GO Terms of Interacting Partners?		Regulation Of Viral Process Positive Regulation Of Viral Process Negative Regulation Of Viral Process Innate Immune Response Nucleus Organization Immune System Process Positive Regulation Of Viral Genome Replication Immune Response Defense Response Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity RNA Metabolic Process RNA Splicing Gene Expression Retrograde Transport, Endosome To Golgi Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated MRNA Processing Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear Speck Organization Regulation Of MRNA Processing Regulation Of Tumor Necrosis Factor Production Regulation Of Cytokine-mediated Signaling Pathway Regulation Of RNA Splicing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process MRNA Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity RNA Processing Negative Regulation Of Immune Response	Vesicle Fusion Organelle Fusion Membrane Fusion Vesicle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Exocytosis Exocytosis Establishment Of Vesicle Localization Vesicle Localization Neurotransmitter Secretion Synaptic Vesicle Transport Golgi Vesicle Transport Secretion By Cell Establishment Of Localization In Cell Regulation Of Neurotransmitter Levels Protein Transport Vesicle-mediated Transport Establishment Of Organelle Localization Establishment Of Protein Localization Intracellular Transport Secretion Neurotransmitter Transport Cellular Localization Organelle Localization Vesicle Docking Post-Golgi Vesicle-mediated Transport Protein Localization Membrane Organization Membrane Docking Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane Intracellular Protein Transport Positive Regulation Of Protein Localization To Cell Surface SNARE Complex Assembly Synaptic Transmission Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization To Cell Surface Positive Regulation Of Regulated Secretory Pathway Cellular Protein Localization Transport Positive Regulation Of Peptidase Activity Response To Hydroperoxide Regulation Of Exocytosis Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Signaling Regulation Of Synaptic Plasticity Cell-cell Signaling Organelle Organization Positive Regulation Of Catalytic Activity Endoplasmic Reticulum Calcium Ion Homeostasis
Tagcloud ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers spen taf1b tceb3c truncating wisp3 znf311	cellubrevin coimmunoprecipitation consistent cytoplasmic deleted domains glut1 glut4 immunoprecipitation insulin introduction membrane microinjection neither plasma recombinant requirement responsive resulted site snap stimulated syntaxin translocation vaccinia vamp2 vesicle vesicles
Tagcloud (Difference) ?		15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers spen taf1b tceb3c truncating wisp3 znf311	cellubrevin coimmunoprecipitation consistent cytoplasmic deleted domains glut1 glut4 immunoprecipitation insulin introduction membrane microinjection neither plasma recombinant requirement responsive resulted site snap stimulated syntaxin translocation vaccinia vamp2 vesicle vesicles
Tagcloud (Intersection) ?