NELFE and CACTIN

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
BioGRID (two hybrid)

		NELFE	CACTIN
Description		negative elongation factor complex member E	cactin, spliceosome C complex subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Plasma Membrane Nuclear Body NELF Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Transcription Pausing By RNA Polymerase II	MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Phosphorylation Immune System Process MRNA Processing RNA Splicing Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: CACTIN CCDC57 CEBPA MTUS2 NCOR1 NELFB SRPK1 SRPK2 TNKS TRIM27 VAMP3	5 interacting genes: CLK2 HMGB2 NELFE RNF10 TRIM39
Entrez ID		7936	58509
HPRD ID		01096	18930
Ensembl ID		ENSG00000204356	ENSG00000105298
Uniprot IDs		A0A1U9X830 P18615	Q8WUQ7
PDB IDs		1X5P 2BZ2 2JX2 5OOB 6GML 7YCX 8JJ6 8UHA 8UHD 8UHG 8UI0 8W8E 9J0N 9J0O 9J0P	6QDV 7W5A 7W5B 8C6J 9FMD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Viral Process Negative Regulation Of Type I Interferon Production Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Peptidyl-serine Phosphorylation Nucleoplasm RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Innate Immune Response Membraneless Organelle Assembly Positive Regulation Of Viral Process Defense Response Regulation Of Macromolecule Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Vitamin B2 C/EBP Complex Regulation Of Viral Genome Replication Protein Phosphorylation Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric RNA Splicing Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor Regulation Of Metabolic Process Retrograde Transport, Endosome To Golgi Phosphorylation Cellular Component Assembly Spindle Assembly Organelle Organization Cellular Response To Cytokine Stimulus Negative Regulation Of Macromolecule Metabolic Process White Fat Cell Proliferation Nuclear Speck Regulation Of Viral Life Cycle MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Organization Microtubule Cytoskeleton Organization NELF Complex Response To Tumor Necrosis Factor Regulation Of Primary Metabolic Process Histone Deacetylase Binding Nuclear Matrix
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