NELFE and CCDC57

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NELFE	CCDC57
Description		negative elongation factor complex member E	coiled-coil domain containing 57
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Plasma Membrane Nuclear Body NELF Complex	Cytoplasm Centrosome Centriole Spindle Cytoskeleton Spindle Microtubule Centriolar Satellite
	Molecular Function	Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Transcription Pausing By RNA Polymerase II	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Positive Regulation Of Mitotic Cell Cycle Cilium Assembly
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: CACTIN CCDC57 CEBPA MTUS2 NCOR1 NELFB SRPK1 SRPK2 TNKS TRIM27 VAMP3	148 interacting genes: ABI1 ABI2 ABLIM1 AMOTL2 ANKRD23 AQP1 ARID5A ARL4A AXIN1 BCAR3 BEX2 C19orf44 CATSPERT CBX8 CBY2 CCDC120 CCDC33 CDC20B CEP57L1 CFAP53 COIL CRTC2 CWF19L2 DCLK2 DISC1 DTX2 ECPAS EFHC2 EIF3D EIF4G1 ELOA EMILIN3 ESS2 FAM107A FAM161A FAM161B FAM228A FAM50B FAM90A1 FH FOXD4L1 FTO GFAP GIGYF1 GPBP1 GPKOW GRPEL1 HAUS1 HBA2 HDX IHO1 IKZF3 INCA1 INTS2 JRK KANK2 KIAA0408 KLF1 KLF15 KPRP KRT4 KRT76 KRTAP13-2 KRTAP13-3 LENG1 LINC00526 LZTS1 MAD1L1 MDM1 MFAP1 MT1E MYOZ3 NAB2 NAPRT NCOA5 NELFE NME4 NUMA1 PAK5 PER1 POM121 PPHLN1 PPP1R18 PRAM1 PRDM6 PROSER3 PRPF18 PRPF31 PRR3 PSMB4 PTCHD3 PTPN7 RAB3IL1 RASD1 RBM48 RDM1 RINT1 RNF6 ROBO3 RUSC1 RXRB SAXO4 SFI1 SH3KBP1 SHISA6 SIRPA SLC25A48 SMG9 SNRNP35 SORBS3 SPMIP2 SPMIP6 SPRY1 SYT6 TBC1D22B TCP10L TFIP11 TFPT TIMM44 TLE5 TMEM100 TNNI1 TP53BP2 TRIM14 TRIM29 TSEN54 TSGA10IP TSHZ2 TXLNA USP15 USP2 UTP14C VPS52 YJU2 ZBTB4 ZC2HC1C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF436 ZNF474 ZNF552 ZNF648 ZNF655 ZNF688 ZNF835 ZSWIM3
Entrez ID		7936	284001
HPRD ID		01096	14150
Ensembl ID		ENSG00000204356	ENSG00000176155
Uniprot IDs		A0A1U9X830 P18615	A0A590UJT6 Q2TAC2
PDB IDs		1X5P 2BZ2 2JX2 5OOB 6GML 7YCX 8JJ6 8UHA 8UHD 8UHG 8UI0 8W8E 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Viral Process Negative Regulation Of Type I Interferon Production Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Peptidyl-serine Phosphorylation Nucleoplasm RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Innate Immune Response Membraneless Organelle Assembly Positive Regulation Of Viral Process Defense Response Regulation Of Macromolecule Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Vitamin B2 C/EBP Complex Regulation Of Viral Genome Replication Protein Phosphorylation Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric RNA Splicing Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor Regulation Of Metabolic Process Retrograde Transport, Endosome To Golgi Phosphorylation Cellular Component Assembly Spindle Assembly Organelle Organization Cellular Response To Cytokine Stimulus Negative Regulation Of Macromolecule Metabolic Process White Fat Cell Proliferation Nuclear Speck Regulation Of Viral Life Cycle MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Organization Microtubule Cytoskeleton Organization NELF Complex Response To Tumor Necrosis Factor Regulation Of Primary Metabolic Process Histone Deacetylase Binding Nuclear Matrix	Protein Binding Spliceosomal Complex Nucleus Cytoskeleton MRNA Splicing, Via Spliceosome RNA Splicing Axonemal A Tubule Inner Sheath RNA Splicing, Via Transesterification Reactions
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