WTAP and EXOSC4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		WTAP	EXOSC4
Description		WT1 associated protein	exosome component 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Nuclear Membrane RNA N6-methyladenosine Methyltransferase Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Protein Binding Identical Protein Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Modification	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		Processing of Capped Intron-Containing Pre-mRNA	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Erosive tooth wear (severe vs non-severe) ( 29898447) Iron status biomarkers ( 19084217)	Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		19 interacting genes: ABHD15 BYSL CPNE1 EIF4ENIF1 EXOSC4 GTSE1 MAGEA11 OGT PSMA1 SLIRP SNCA TAB1 TCF12 TNIP1 VPS52 WT1 YWHAQ ZNF239 ZNF572	34 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PRRC2B PTEN SDCBP SKIC2 SMPD4 TSEN15 UPF1 UPF2 UPF3B WTAP
Entrez ID		9589	54512
HPRD ID		09259	16221
Ensembl ID		ENSG00000146457	ENSG00000178896
Uniprot IDs		A0A087X1R4 Q15007	Q9NPD3
PDB IDs		7VF2 7VF5 7YFJ 7YG4	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Cytoplasm Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Ectodermal Digestive Tract Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catabolic Process Negative Regulation Of Translation Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Short-chain Carboxylesterase Activity Regulation Of Neuron Differentiation Positive Regulation Of Gene Expression Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Catabolic Process Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nuclear RNA Surveillance Nuclear MRNA Surveillance RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing MRNA Metabolic Process RRNA 3'-end Processing TRNA Decay SnRNA Metabolic Process RNA Metabolic Process Macromolecule Catabolic Process SnRNA 3'-end Processing RRNA Processing 3'-5'-RNA Exonuclease Activity RRNA Metabolic Process SnRNA Processing RNA Binding Nucleic Acid Metabolic Process CUT Catabolic Process RRNA Catabolic Process RNA 3'-end Processing Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression RNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Macromolecule Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolus Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Sno(s)RNA Metabolic Process TRNA Metabolic Process Exoribonuclease Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process
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