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WTAP and TAB1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
WTAP
TAB1
Gene Name
Wilms tumor 1 associated protein
TGF-beta activated kinase 1/MAP3K7 binding protein 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Nuclear Speck
Nuclear Membrane
MIS Complex
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Protein Complex
Molecular Function
Catalytic Activity
Protein Binding
Enzyme Activator Activity
Kinase Activator Activity
Protein Complex Binding
Mitogen-activated Protein Kinase P38 Binding
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Processing
Cell Cycle
RNA Splicing
MRNA Methylation
Activation Of MAPKKK Activity
Activation Of MAPK Activity
In Utero Embryonic Development
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Heart Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Lung Development
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
TRAF6 mediated induction of TAK1 complex
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
FCERI mediated NF-kB activation
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
activated TAK1 mediates p38 MAPK activation
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Fc epsilon receptor (FCERI) signaling
Interleukin-1 signaling
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Iron status biomarkers (
19084217
)
IgG glycosylation (
23382691
)
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
7 interactors:
CPNE1
IKZF1
MAGEA11
TAB1
VPS52
WT1
YWHAQ
61 interactors:
ACAP3
ARAP1
ASRGL1
BMPR1A
C2orf44
C9orf78
CARD11
CASP6
CDK5RAP3
CFL1
CKB
CORO1A
DBN1
EPRS
FADD
FN1
GIT1
HNRNPR
KIFC2
LAP3
LCMT1
MAP3K7
MAPK11
MAPK14
MAPKAPK5
MICAL1
MON1A
MTG2
NR2C2
NXPH3
OGT
PDCD6IP
PHACTR3
PHC2
POLDIP2
POLR3D
PPP1R7
PPP2CB
PPP2R1A
PRKAR1A
PTPMT1
RBX1
RPL10
RPLP1
SERPINA4
SMAD6
SMAD7
SNRNP35
TAB2
TAB3
TRAF2
TRAF6
TRIP6
TRPC4AP
TSSC4
URB1
WTAP
XIAP
XPO7
YWHAG
ZMYND11
Entrez ID
9589
10454
HPRD ID
09259
04012
Ensembl ID
ENSG00000146457
ENSG00000100324
Uniprot IDs
Q15007
A8K6K3
Q15750
PDB IDs
2J4O
2POM
2POP
2YDS
2YIY
4AY5
4AY6
4GS6
4KA3
4L3P
4L53
Enriched GO Terms of Interacting Partners
?
Organ Development
Positive Regulation Of Neutrophil Differentiation
Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation
Tube Development
Positive Regulation Of Metanephric Ureteric Bud Development
Thorax And Anterior Abdomen Determination
Visceral Serous Pericardium Development
Posterior Mesonephric Tubule Development
Adrenal Cortex Formation
Embryonic Ectodermal Digestive Tract Development
Positive Regulation Of Developmental Growth
Negative Regulation Of Glomerulus Development
Negative Regulation Of Glomerular Mesangial Cell Proliferation
System Development
Zygotic Determination Of Anterior/posterior Axis, Embryo
Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development
Negative Regulation Of Cell Proliferation Involved In Kidney Development
Positive Regulation Of Growth
Negative Regulation Of Female Gonad Development
Cardiac Muscle Cell Fate Commitment
Ectodermal Cell Differentiation
Multicellular Organismal Development
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of NK T Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Regulation Of Glomerular Mesangial Cell Proliferation
Anatomical Structure Development
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryo Development
Activation Of MAPKKK Activity
S-shaped Body Morphogenesis
Positive Regulation Of Granulocyte Differentiation
Respiratory System Development
Regulation Of Developmental Growth
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Diaphragm Development
Negative Regulation Of Gene Expression
Positive Regulation Of Male Gonad Development
Regulation Of Female Gonad Development
Negative Regulation Of Biosynthetic Process
Developmental Process
Camera-type Eye Development
Seminiferous Tubule Development
Glomerular Basement Membrane Development
Eye Development
Glomerular Visceral Epithelial Cell Differentiation
Lymph Node Development
Muscle Cell Fate Commitment
Peyer's Patch Development
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Catalytic Activity
Positive Regulation Of Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Regulation Of Signaling
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Innate Immune Response
Positive Regulation Of Cellular Protein Metabolic Process
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Phosphorus Metabolic Process
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Activation Of Protein Kinase Activity
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of MAP Kinase Activity
Intracellular Signal Transduction
Immune Response
Positive Regulation Of MAP Kinase Activity
Activation Of MAPK Activity
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Kinase Activity
Immune Response-regulating Signaling Pathway
Response To Growth Factor
Positive Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Regulation Of Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Immune Response
Signal Transduction By Phosphorylation
Apoptotic Process
Stress-activated MAPK Cascade
Tagcloud
?
5z
attenuated
ccr7
chemokine
collectively
constitutive
ikappab
ikk
importantly
invasion
jnk
jun
lymphatic
mb
mda
mediator
motif
o
orthotopic
oxozeaenol
p38
phospho
promotes
repressed
strongly
suppressed
tak1
tgf
unclear
Tagcloud (Difference)
?
5z
attenuated
ccr7
chemokine
collectively
constitutive
ikappab
ikk
importantly
invasion
jnk
jun
lymphatic
mb
mda
mediator
motif
o
orthotopic
oxozeaenol
p38
phospho
promotes
repressed
strongly
suppressed
tak1
tgf
unclear
Tagcloud (Intersection)
?