NCF2

Description		neutrophil cytosolic factor 2
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Small GTPase Binding
	Biological Process	Superoxide Metabolic Process Phagocytosis Cellular Defense Response Superoxide Anion Generation Innate Immune Response Respiratory Burst
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 19838195 26502338 26606652 27399966 28714469 33272962) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		4688
HPRD ID		01991
Ensembl ID		ENSG00000116701
Uniprot IDs		A0A0S2Z457 A0A8V8TMB9 P19878
PDB IDs		1E96 1HH8 1K4U 1OEY 1WM5 2DMO 8WEJ
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Regulation Of Respiratory Burst Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Superoxide-generating NAD(P)H Oxidase Activity Leukocyte Aggregation Inflammatory Response Positive Regulation Of Cell Growth Reactive Oxygen Species Biosynthetic Process Calprotectin Complex Neutrophil Aggregation Regulation Of Innate Immune Response Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Growth Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Lamellipodium Organization Cellular Response To L-glutamine Phagolysosome Peptidyl-cysteine S-nitrosylation Regulation Of Lamellipodium Assembly Regulation Of Toll-like Receptor Signaling Pathway Defense Response Erythrocyte Enucleation Toll-like Receptor 4 Binding Positive Regulation Of Cell Projection Organization Innate Immune Response Arachidonate Binding Regulation Of Lamellipodium Organization Defense Response To Fungus G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Leukocyte Cell-cell Adhesion Regulation Of Cell Growth Electron Transfer Activity Regulation Of Immune System Process Autocrine Signaling Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Membrane Defense Response To Symbiont Superoxide-generating NADPH Oxidase Activator Activity Defense Response To Other Organism Protein Kinase Binding Response To Ketone Positive Regulation Of Defense Response Thioesterase Binding Chronic Inflammatory Response
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