NCF2 and CYBA

Number of citations of the paper that reports this interaction (PMID 11893732)
70

Data Source:
BioGRID (unspecified method)
HPRD (in vitro, in vivo)

		NCF2	CYBA
Gene Name		neutrophil cytosolic factor 2	cytochrome b-245, alpha polypeptide
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleolus Cytoplasm Cytosol Phagolysosome NADPH Oxidase Complex	Mitochondrion Endosome Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane NADPH Oxidase Complex Neuronal Cell Body Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Protein C-terminus Binding Electron Carrier Activity Rac GTPase Binding	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Cellular Defense Response Aging Response To Glucose Response To Activity Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Response To Laminar Fluid Shear Stress Response To Drug Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Respiratory Burst Positive Regulation Of Blood Pressure Vascular Endothelial Growth Factor Receptor Signaling Pathway Interaction With Host Response To Hyperoxia Phagosome Maturation	Positive Regulation Of Endothelial Cell Proliferation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Smooth Muscle Hypertrophy Cytochrome Complex Assembly Positive Regulation Of Cell Growth Response To Nutrient Levels Response To Drug Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Interaction With Host Oxidation-reduction Process Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Gamma Radiation Phagosome Maturation
Pathways		Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ACTB CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1	12 interactors: CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2
Entrez ID		4688	1535
HPRD ID		01991	01989
Ensembl ID		ENSG00000116701	ENSG00000051523
Uniprot IDs		P19878	B4DT46 P13498
PDB IDs		1E96 1HH8 1K4U 1OEY 1WM5 2DMO	1WLP
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Innate Immune Response Immune Response Immune System Process Response To Stress Defense Response Single Organismal Cell-cell Adhesion Neutrophil Aggregation Regulation Of Body Fluid Levels Chemotaxis Wound Healing Homotypic Cell-cell Adhesion Hydrogen Peroxide Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Sequestering Of Zinc Ion Cell Adhesion Response To External Stimulus Phagosome Maturation Blood Coagulation Inflammatory Response Hemostasis Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Antigen Processing And Presentation Of Peptide Antigen Movement Of Cell Or Subcellular Component Hydrogen Peroxide Biosynthetic Process Chemokine Production Regulation Of Hydrogen Peroxide Metabolic Process Sequestering Of Metal Ion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Leukocyte Aggregation Antigen Processing And Presentation Regulation Of Respiratory Burst Respiratory Burst Ephrin Receptor Signaling Pathway Chronic Inflammatory Response Positive Regulation Of Lamellipodium Assembly Interaction With Host Leukocyte Cell-cell Adhesion Leukocyte Chemotaxis Cellular Zinc Ion Homeostasis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Reactive Oxygen Species Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Cell Projection Assembly	Respiratory Burst Superoxide Anion Generation Vascular Endothelial Growth Factor Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Superoxide Metabolic Process Phagosome Maturation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Interaction With Host Antigen Processing And Presentation Reactive Oxygen Species Metabolic Process Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Hyperoxia Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response Defense Response Immune System Process Cellular Defense Response Innate Immune Response Response To Stress Oxidation-reduction Process Cellular Stress Response To Acidic PH Positive Regulation Of Phosphorylation Cellular Response To Stimulus Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Signal Transduction Metabolic Process Oxygen Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Engulfment Of Apoptotic Cell Positive Regulation Of JNK Cascade Regulation Of Cellular Protein Metabolic Process Response To Drug Signaling Mast Cell Chemotaxis Regulation Of Integrin Biosynthetic Process Positive Regulation Of Stress-activated MAPK Cascade
Tagcloud ?		anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide	anion besides biopsies chl copy cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf2 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf2 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide