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NCF2 and S100A8
Number of citations of the paper that reports this interaction (PubMedID
15642721
)
0
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
NCF2
S100A8
Description
neutrophil cytosolic factor 2
S100 calcium binding protein A8
Image
GO Annotations
Cellular Component
Acrosomal Vesicle
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Phagolysosome
NADPH Oxidase Complex
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Membrane
Extracellular Matrix
Secretory Granule Lumen
Intermediate Filament Cytoskeleton
Extracellular Exosome
Calprotectin Complex
S100A8 Complex
Molecular Function
Protein Binding
Electron Transfer Activity
Superoxide-generating NAD(P)H Oxidase Activity
Superoxide-generating NADPH Oxidase Activator Activity
Small GTPase Binding
Calcium Ion Binding
Protein Binding
Microtubule Binding
Zinc Ion Binding
Toll-like Receptor 4 Binding
Metal Ion Binding
Calcium-dependent Protein Binding
Arachidonate Binding
RAGE Receptor Binding
Biological Process
Superoxide Metabolic Process
Phagocytosis
Cellular Defense Response
Superoxide Anion Generation
Innate Immune Response
Respiratory Burst
Immune System Process
Leukocyte Migration Involved In Inflammatory Response
Chronic Inflammatory Response
Peptide Secretion
Positive Regulation Of Peptide Secretion
Autophagy
Apoptotic Process
Chemotaxis
Inflammatory Response
Response To Zinc Ion
Astrocyte Development
Peptidyl-cysteine S-nitrosylation
Positive Regulation Of Cell Growth
Neutrophil Chemotaxis
Response To Lipopolysaccharide
Regulation Of Toll-like Receptor Signaling Pathway
Autocrine Signaling
Defense Response To Bacterium
Endothelial Cell Migration
Innate Immune Response
Response To Ethanol
Positive Regulation Of Inflammatory Response
Defense Response To Fungus
Regulation Of Cytoskeleton Organization
Neutrophil Aggregation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
ROS and RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
RAC1 GTPase cycle
RAC2 GTPase cycle
RAC3 GTPase cycle
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
RHO GTPases Activate NADPH Oxidases
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Metal sequestration by antimicrobial proteins
Drugs
Dextromethorphan
Calcium
Zinc
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Celiac disease (
31591516
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Systemic lupus erythematosus (
19838195
26502338
26606652
27399966
28714469
33272962
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Asthma (
31619474
)
Matrix metalloproteinase-8 levels (
29212897
)
Monocyte count (
32888494
)
Interacting Genes
15 interacting genes:
AKT1
CDC42
CYBA
CYBB
GOLGA2
KIFAP3
NCF1
NCF4
PRDX6
PRKDC
RAC1
RAC2
S100A8
S100A9
SYTL1
22 interacting genes:
APP
CDKN1A
CEACAM3
CHGB
ERG28
GDF9
IGSF21
KLC2
LRIF1
NCF2
PCNA
PDCD11
PPIA
PRMT1
PTEN
RAB17
S100A9
TP53
TUBA1A
TUBA4A
TUBB
UNC119
Entrez ID
4688
6279
HPRD ID
01991
00471
Ensembl ID
ENSG00000116701
ENSG00000143546
Uniprot IDs
A0A0S2Z457
A0A8V8TMB9
P19878
P05109
PDB IDs
1E96
1HH8
1K4U
1OEY
1WM5
2DMO
8WEJ
1MR8
1XK4
4GGF
4XJK
5HLO
5HLV
5W1F
6DS2
7QUV
8SJB
8SJC
Enriched GO Terms of Interacting Partners
?
NADPH Oxidase Complex
Respiratory Burst
Superoxide Anion Generation
Superoxide Metabolic Process
Reactive Oxygen Species Metabolic Process
Regulation Of Respiratory Burst
Hydrogen Peroxide Metabolic Process
Hydrogen Peroxide Biosynthetic Process
Superoxide-generating NAD(P)H Oxidase Activity
Leukocyte Aggregation
Inflammatory Response
Positive Regulation Of Cell Growth
Reactive Oxygen Species Biosynthetic Process
Calprotectin Complex
Neutrophil Aggregation
Regulation Of Innate Immune Response
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Growth
Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
Positive Regulation Of Lamellipodium Organization
Cellular Response To L-glutamine
Phagolysosome
Peptidyl-cysteine S-nitrosylation
Regulation Of Lamellipodium Assembly
Regulation Of Toll-like Receptor Signaling Pathway
Defense Response
Erythrocyte Enucleation
Toll-like Receptor 4 Binding
Positive Regulation Of Cell Projection Organization
Innate Immune Response
Arachidonate Binding
Regulation Of Lamellipodium Organization
Defense Response To Fungus
G Protein-coupled Receptor Signaling Pathway Involved In Heart Process
Leukocyte Cell-cell Adhesion
Regulation Of Cell Growth
Electron Transfer Activity
Regulation Of Immune System Process
Autocrine Signaling
Response To Fungus
Regulation Of Respiratory Burst Involved In Inflammatory Response
Membrane
Defense Response To Symbiont
Superoxide-generating NADPH Oxidase Activator Activity
Defense Response To Other Organism
Protein Kinase Binding
Response To Ketone
Positive Regulation Of Defense Response
Thioesterase Binding
Chronic Inflammatory Response
Response To Light Stimulus
Molecular Function Activator Activity
PCNA-p21 Complex
Enzyme Binding
Response To Radiation
Regulation Of Phosphorus Metabolic Process
Regulation Of Growth
RAGE Receptor Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
Microtubule-based Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Nuclear Envelope Lumen
Heparan Sulfate Binding
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Phosphate Metabolic Process
Stress-induced Premature Senescence
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Forebrain Morphogenesis
Cytoskeleton-dependent Intracellular Transport
Mitotic G1 DNA Damage Checkpoint Signaling
Negative Regulation Of Growth
Regulation Of DNA Biosynthetic Process
Replicative Senescence
Synapse Maturation
Cellular Response To UV
Mitotic G1/S Transition Checkpoint Signaling
Response To L-glutamate
Structural Constituent Of Cytoskeleton
Synapse Organization
Protein-containing Complex
Protein Serine/threonine Kinase Binding
Negative Regulation Of Protein Phosphorylation
Heart Development
Cellular Response To Light Stimulus
Circadian Behavior
Rhythmic Behavior
Response To Amino Acid
Regulation Of DNA Replication
Negative Regulation Of Phosphorylation
Positive Regulation Of Protein Metabolic Process
Dentate Gyrus Development
Regulation Of Cellular Component Organization
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Synapse Organization
Positive Regulation Of Excitatory Postsynaptic Potential
Recycling Endosome
Regulation Of Reactive Oxygen Species Metabolic Process
Cytosol
Regulation Of Cellular Response To Stress
Negative Regulation Of DNA Metabolic Process
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