NCF2 and SYTL1

Number of citations of the paper that reports this interaction (PubMedID 11278853)
0

Data Source:
HPRD (in vitro)

		NCF2	SYTL1
Description		neutrophil cytosolic factor 2	synaptotagmin like 1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Membrane Phagolysosome NADPH Oxidase Complex	Plasma Membrane Membrane Microvillus Membrane Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Small GTPase Binding	Protein Binding Small GTPase Binding Neurexin Family Protein Binding
	Biological Process	Superoxide Metabolic Process Phagocytosis Cellular Defense Response Superoxide Anion Generation Innate Immune Response Respiratory Burst	Intracellular Protein Transport Exocytosis
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	TBC/RABGAPs
Drugs		Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 19838195 26502338 26606652 27399966 28714469 33272962) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1	7 interacting genes: AKT1 NCF1 NCF2 NRXN1 RAB27A RAB27B RAB8A
Entrez ID		4688	84958
HPRD ID		01991	12156
Ensembl ID		ENSG00000116701	ENSG00000142765
Uniprot IDs		A0A0S2Z457 A0A8V8TMB9 P19878	Q8IYJ3
PDB IDs		1E96 1HH8 1K4U 1OEY 1WM5 2DMO 8WEJ
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Regulation Of Respiratory Burst Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Superoxide-generating NAD(P)H Oxidase Activity Leukocyte Aggregation Inflammatory Response Positive Regulation Of Cell Growth Reactive Oxygen Species Biosynthetic Process Calprotectin Complex Neutrophil Aggregation Regulation Of Innate Immune Response Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Growth Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Lamellipodium Organization Cellular Response To L-glutamine Phagolysosome Peptidyl-cysteine S-nitrosylation Regulation Of Lamellipodium Assembly Regulation Of Toll-like Receptor Signaling Pathway Defense Response Erythrocyte Enucleation Toll-like Receptor 4 Binding Positive Regulation Of Cell Projection Organization Innate Immune Response Arachidonate Binding Regulation Of Lamellipodium Organization Defense Response To Fungus G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Leukocyte Cell-cell Adhesion Regulation Of Cell Growth Electron Transfer Activity Regulation Of Immune System Process Autocrine Signaling Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Membrane Defense Response To Symbiont Superoxide-generating NADPH Oxidase Activator Activity Defense Response To Other Organism Protein Kinase Binding Response To Ketone Positive Regulation Of Defense Response Thioesterase Binding Chronic Inflammatory Response	Myosin V Binding Establishment Of Protein Localization Protein Localization To Synapse Phagolysosome GDP Binding Protein Localization To Cell Junction Superoxide-generating NADPH Oxidase Activator Activity Superoxide-generating NAD(P)H Oxidase Activity Secretion By Cell NADPH Oxidase Complex Trans-Golgi Network Transport Vesicle Vesicle-mediated Transport Secretion Localization Within Membrane Respiratory Burst Superoxide Anion Generation Phosphatidylinositol-3,4-bisphosphate Binding Exocytosis Multivesicular Body Membrane Exocytic Vesicle Establishment Of Protein Localization To Membrane Cellular Localization Establishment Of Localization In Cell Superoxide Metabolic Process Multivesicular Body Sorting Pathway Receptor Localization To Synapse Cellular Defense Response Protein Localization To Membrane Intracellular Protein Localization GTPase Activity Establishment Of Protein Localization To Plasma Membrane Electron Transfer Activity Protein Localization To Cilium Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Calcium Ion Regulation Of TRNA Methylation GTP Binding Neuronal Cell Body Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Positive Regulation Of Exocytosis Positive Regulation Of Protein Localization To Membrane Vesicle-mediated Transport In Synapse
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