BRE and SUMO2

Number of citations of the paper that reports this interaction (PMID 23211528)
15

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		BRE	SUMO2
Gene Name		brain and reproductive organ-expressed (TNFRSF1A modulator)	small ubiquitin-like modifier 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Ubiquitin Ligase Complex Nucleus Cytoplasm BRCA1-A Complex BRISC Complex	Nucleus Nucleoplasm PML Body
	Molecular Function	Peroxisome Targeting Sequence Binding Tumor Necrosis Factor Receptor Binding Protein Binding Polyubiquitin Binding	Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Signal Transduction Response To Ionizing Radiation Chromatin Modification G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: BABAM1 FAM175A GFI1B NCOA3 SUMO2 UBC UBE2D1	91 interactors: ALAS1 ARL13A ARNTL ATXN1 ATXN7 AURKB BAD BCL11A BLM BRCC3 BRE C18orf25 CCNE2 CDCA8 CENPC CHAF1A CHD3 CMTM6 CORO2A CSNK2B CUL3 FAM175A FOS HDAC4 HDAC9 HIF1A HIPK2 HNF4A HOMEZ HSF2 JUN KALRN KDM1A KRT14 KRT5 KRT8 LEF1 MAF1 MAST2 MDC1 MSX1 MYB NFKBIA PARP1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAC1 RANGAP1 RB1 RNF111 RNF4 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SH3KBP1 SLC22A2 SNCA SOX10 SOX6 SP100 STK24 SUMO1 TDG TDP2 TEAD3 TNIP1 TOPORS TP53BP2 TRIM63 UBA2 UBE2I USP25 USPL1 VIM WRN XPC ZBTB1 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM5
Entrez ID		9577	6613
HPRD ID		08498	04332
Ensembl ID		ENSG00000158019	ENSG00000188612
Uniprot IDs		Q9NXR7	P61956
PDB IDs			1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2RPQ 3UIN 3UIO
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Positive Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Catabolic Process Chromatin Organization Positive Regulation Of DNA Repair G2 DNA Damage Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA Repair Regulation Of DNA-templated Transcription In Response To Stress Cell Cycle Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Nucleobase-containing Compound Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Protein Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress DNA Repair Cellular Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus	Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding RNA Metabolic Process Cellular Metabolic Process Gene Expression Chromosome Organization Organelle Organization Regulation Of DNA Binding Biosynthetic Process Response To Stimulus Regulation Of Cellular Process Cellular Response To Stimulus Negative Regulation Of Binding Protein Modification By Small Protein Conjugation Peptidyl-amino Acid Modification Regulation Of Cell Differentiation Regulation Of Signal Transduction Cellular Response To Stress
Tagcloud ?		cdna cerebellar damaging encodes fas gives homologous hybrid immunoprecipitation interacted irradiation juxtamembrane kb kilodaltons library modulate neurotrophin nfkappab organs p55 p75 reproductive responsive rise screen tnf uv verified yeast	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Difference) ?		cdna cerebellar damaging encodes fas gives homologous hybrid immunoprecipitation interacted irradiation juxtamembrane kb kilodaltons library modulate neurotrophin nfkappab organs p55 p75 reproductive responsive rise screen tnf uv verified yeast	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Intersection) ?