BABAM2 and PPDPF

Number of citations of the paper that reports this interaction (PubMedID 34975328)
48

Data Source:
BioGRID (pull down)

		BABAM2	PPDPF
Description		BRISC and BRCA1 A complex member 2	pancreatic progenitor cell differentiation and proliferation factor
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex	Mitochondrion
	Molecular Function	Peroxisome Targeting Sequence Binding Tumor Necrosis Factor Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Signal Transduction Response To Ionizing Radiation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Cellular Response To Ionizing Radiation Regulation Of DNA Damage Checkpoint	Liver Development Cell Differentiation TOR Signaling TORC1 Signaling
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 29617998) Low density lipoprotein cholesterol levels ( 33339817) Urate levels ( 31578528) Uterine fibroids ( 31649266)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Estimated glomerular filtration rate ( 31152163) Prostate cancer ( 23535732) Serum metabolite levels ( 33031748)
Interacting Genes		7 interacting genes: BABAM1 GFI1B NCOA3 PPDPF SUMO2 UBC UBE2D1	11 interacting genes: BABAM2 CTSC DDB1 DNAJB1 GLMN MT2A PLSCR1 PRMT1 RIPK1 RPTOR TRIP6
Entrez ID		9577	79144
HPRD ID		08498	12750
Ensembl ID		ENSG00000158019	ENSG00000125534
Uniprot IDs		Q9NXR7	Q9H3Y8
PDB IDs		6H3C 6R8F 8PVY 8PY2
Enriched GO Terms of Interacting Partners?		Protein Tag Activity TORC1 Signaling Organelle Envelope	Positive Regulation Of Protein Metabolic Process Cell Death Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Cytoplasm Regulation Of Signal Transduction Programmed Cell Death Regulation Of Immune System Process Regulation Of Protein Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Cellular Response To Stress Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Myeloid Cell Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Translational Initiation Positive Regulation Of Gene Expression Protein Localization To Lysosome GATOR1 Complex Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation TORC1 Signaling Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of TORC1 Signaling Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Phosphate Metabolic Process Regulation Of Viral Genome Replication Protein-containing Complex Binding DNA Damage Response Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition TOR Signaling Cellular Response To Amino Acid Stimulus Lead Ion Binding Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Hepatocyte Growth Factor Receptor Binding Positive Regulation Of TOR Signaling Chromatin Organization Protein Localization To Vacuole Protein-folding Chaperone Binding Regulation Of Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Protein Folding Phosphatidylserine Biosynthetic Process Mercury Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface
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