BRE and GFI1B

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BRE	GFI1B
Gene Name		brain and reproductive organ-expressed (TNFRSF1A modulator)	growth factor independent 1B transcription repressor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Ubiquitin Ligase Complex Nucleus Cytoplasm BRCA1-A Complex BRISC Complex	Nucleus Transcription Factor Complex Nuclear Matrix
	Molecular Function	Peroxisome Targeting Sequence Binding Tumor Necrosis Factor Receptor Binding Protein Binding Polyubiquitin Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Signal Transduction Response To Ionizing Radiation Chromatin Modification G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Chromatin Modification Hemopoiesis Regulation Of Histone H3-K4 Methylation
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: BABAM1 FAM175A GFI1B NCOA3 SUMO2 UBC UBE2D1	71 interactors: ACTN1 AES AGPAT6 AGRN AJUBA ANKS3 ATXN2 BECN1 BEGAIN BEND5 BRCA1 BRE CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRD1 ZNRF3
Entrez ID		9577	8328
HPRD ID		08498	05088
Ensembl ID		ENSG00000158019	ENSG00000165702
Uniprot IDs		Q9NXR7	Q5VTD9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Positive Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Catabolic Process Chromatin Organization Positive Regulation Of DNA Repair G2 DNA Damage Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA Repair Regulation Of DNA-templated Transcription In Response To Stress Cell Cycle Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Nucleobase-containing Compound Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Protein Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress DNA Repair Cellular Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus	Regulation Of Cellular Process Cell Communication Regulation Of Cellular Component Organization Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Signaling Cellular Response To Stimulus Signal Transduction Response To Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Growth Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Canonical Wnt Signaling Pathway Developmental Process Secretion Negative Regulation Of Signaling Regulation Of Locomotion Cellular Process Regulation Of Cellular Component Movement Focal Adhesion Assembly Protein Localization Protein Ubiquitination Cellular Localization Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Cell-substrate Adhesion Adherens Junction Assembly Cell Differentiation Cellular Component Assembly Neurogenesis Auditory Receptor Cell Fate Commitment Anatomical Structure Development Regulation Of Gene Expression Regulation Of Proteolysis Regulation Of Apoptotic Process Cell-substrate Junction Assembly Regulation Of I-kappaB Kinase/NF-kappaB Signaling Secretion By Cell Regulation Of Cell Proliferation Receptor Clustering Regulation Of Vesicle-mediated Transport
Tagcloud ?		cdna cerebellar damaging encodes fas gives homologous hybrid immunoprecipitation interacted irradiation juxtamembrane kb kilodaltons library modulate neurotrophin nfkappab organs p55 p75 reproductive responsive rise screen tnf uv verified yeast	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Difference) ?		cdna cerebellar damaging encodes fas gives homologous hybrid immunoprecipitation interacted irradiation juxtamembrane kb kilodaltons library modulate neurotrophin nfkappab organs p55 p75 reproductive responsive rise screen tnf uv verified yeast	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Intersection) ?