BAG2 and LRRK1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		BAG2	LRRK1
Description		BAG cochaperone 2	leucine rich repeat kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Axon Dendrite Protein Folding Chaperone Complex Dendritic Microtubule	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Transmembrane Transporter Binding Tau Protein Binding Protein-folding Chaperone Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Folding Positive Regulation Of Protein Processing Protein Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Stabilization Positive Regulation Of Proteasomal Protein Catabolic Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways		Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS			Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)
Interacting Genes		17 interacting genes: CCAR2 DAPK1 DISC1 DNAJC6 HSPA1A HSPA4 HSPA8 LRRK1 LRRK2 MAPKAPK2 MFHAS1 NOTCH3 PINK1 PPIH SLU7 WDR77 WDR83	53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4
Entrez ID		9532	79705
HPRD ID		04859	14319
Ensembl ID		ENSG00000112208	ENSG00000154237
Uniprot IDs		O95816	Q38SD2
PDB IDs			8E04 8E05 8E06 8FAC
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Cytoplasm Negative Regulation Of Intrinsic Apoptotic Signaling Pathway ATP-dependent Protein Folding Chaperone Nucleotide Binding ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Clathrin Coat Disassembly Positive Regulation Of Wnt Signaling Pathway Regulation Of Synaptic Vesicle Transport ATP Binding Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Stability Protein-containing Complex Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis MRNA Metabolic Process Spliceosomal Complex RNA Splicing Response To Stress Protein Serine/threonine Kinase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Heat Shock Protein Binding MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Oxidative Stress Protein Folding Regulation Of Protein-containing Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing Cellular Response To Stress Negative Regulation Of Autophagosome Assembly Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Response To Unfolded Protein Protein Kinase Activity Adenyl-nucleotide Exchange Factor Activity Mitochondrion Organization Cellular Response To Chemical Stress Regulation Of Cellular Response To Stress Intracellular Signal Transduction Syntaxin-1 Binding Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Cytosol Calcium/calmodulin-dependent Protein Kinase Activity Ubiquitin Protein Ligase Binding	Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy
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