TECR and GET1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TECR	GET1
Description		trans-2,3-enoyl-CoA reductase	guided entry of tail-anchored proteins factor 1
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Very-long-chain Fatty Acyl-CoA Dehydrogenase Activity Very-long-chain Enoyl-CoA Reductase Activity	Protein Binding Protein-membrane Adaptor Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane
Pathways		Synthesis of very long-chain fatty acyl-CoAs	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		33 interacting genes: AQP6 ARL13B CD79A CLDN5 CRB3 CREB3 CREB3L1 ELOVL4 ERGIC3 FAM209A FBXO7 FKBP7 GET1 GOLT1A HACD1 JAGN1 MMGT1 MUC1 NOS3 PAXIP1 PGRMC2 PTEN RETREG3 SAR1A SLC10A6 SLC18A1 SLC35H1 SLC71A2 SLC7A14 STING1 STOM TFAM VMA21	28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42
Entrez ID		9524	7485
HPRD ID		17076	04224
Ensembl ID		ENSG00000099797	ENSG00000182093
Uniprot IDs		B3KSQ1 B4DR74 Q9NZ01	O00258
PDB IDs		2DZJ	6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Schmidt-Lanterman Incisure Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Protein Binding Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Intrinsic Apoptotic Signaling Pathway	Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex
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