GDF15 and ALOX5AP

Data Source: HiPPIP (Novel)

		GDF15	ALOX5AP
Name		growth differentiation factor 15	arachidonate 5-lipoxygenase activating protein
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Extracellular Matrix Extracellular Exosome	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Arachidonate Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Leukocyte Migration Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Cellular Response To Chemical Stress Energy Homeostasis GDF15-GFRAL Signaling Pathway Response To Metformin Positive Regulation Of Myoblast Fusion	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Leukotriene Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification
Pathways		None	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX)
Drugs		None	DG031 AM103 Fiboflapon Veliflapon MK-886
GWAS		Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Coffee consumption ( 31046077 ) Growth differentiation factor-15 levels ( 29628937 ) Hyperemesis gravidarum ( 29563502 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Severity of nausea and vomiting of pregnancy ( 29563502 )	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145 ) General risk tolerance (MTAG) ( 30643258 ) Non-word repetition ( 23738518 )
Novel Interactors		13 novel interactors: ALOX5AP BORCS8-MEF2B BRME1 COPE EHF FCHO1 HOMER3 IL27RA MAST3 MED26 PDE4C SIN3B SULT2A1	2 novel interactors: FLT1 GDF15
Interacting Genes		7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3	10 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B
Entrez ID		9518	241
HPRD ID		05608	04742
Ensembl ID		ENSG00000130513	ENSG00000132965
Uniprot IDs		Q99988	A0A087WW23 P20292
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	2Q7M 2Q7R 6VGC 6VGI
GO Terms Enriched among Interactors		None	Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Biosynthetic Process Leukocyte Chemotaxis Leukotriene Metabolic Process Cell Chemotaxis Regulation Of Protein Secretion Long-chain Fatty Acid Biosynthetic Process Leukocyte Migration Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Nuclear Membrane Negative Regulation Of Endothelial Cell Proliferation Membrane Icosanoid Biosynthetic Process Nitrate Transmembrane Transporter Activity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Metformin Leukotriene A4 Metabolic Process Locomotion Leukotriene Production Involved In Inflammatory Response Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Lipoxin Biosynthetic Process Positive Regulation Of Developmental Process Arachidonate 12(S)-lipoxygenase Activity Chemotaxis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chloride Transmembrane Transport G Protein-coupled Receptor Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Protein Secretion Uracil Transmembrane Transport Thymine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Hypoxanthine Transport Purine Nucleoside Transmembrane Transporter Activity Cellular Response To Morphine Soluble NSF Attachment Protein Activity SNARE Complex Disassembly