GDF15 and MED26

		GDF15	MED26
Description		growth differentiation factor 15	mediator complex subunit 26
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Leukocyte Migration Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Cellular Response To Chemical Stress Energy Homeostasis GDF15-GFRAL Signaling Pathway Response To Metformin Positive Regulation Of Myoblast Fusion	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
Interacting Genes		7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3	8 interacting genes: AURKA CDK8 CTDP1 MED12 MED8 MED9 RBP1 SREBF1
Entrez ID		9518	9441
HPRD ID		05608	05437
Ensembl ID		ENSG00000130513	ENSG00000105085
Uniprot IDs		Q99988	O95402
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	5ODD 6ZV3 7EMF 7ENA 7ENC 7ENJ 8GXQ 8GXS
Enriched GO Terms of Interacting Partners?			Mediator Complex CKM Complex Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Transcription Coregulator Activity Spindle Midzone Core Mediator Complex Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Response To Metformin Positive Regulation Of DNA-templated Transcription, Elongation Transcription Preinitiation Complex Assembly Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Fatty Acid Metabolic Process Protein Modification Process TFIIF-class Transcription Factor Complex Binding Negative Regulation Of Developmental Growth Axis Elongation Involved In Somitogenesis Regulation Of Transcription Elongation By RNA Polymerase II All-trans-retinol Binding Sterol Response Element Binding Positive Regulation Of Oocyte Maturation Ubiquitin Ligase Complex Regulation Of DNA-templated Transcription Elongation Positive Regulation Of RNA Metabolic Process Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Regulation Of Ketone Metabolic Process Regulation Of Heart Rate By Chemical Signal Positive Regulation Of Lipid Metabolic Process Developmental Growth Involved In Morphogenesis GDF15-GFRAL Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Vitamin A Metabolic Process Retinoic Acid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Mitotic Cell Cycle Phase Transition
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