GDF15 and COPE

		GDF15	COPE
Description		growth differentiation factor 15	coat protein complex I subunit epsilon
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Extracellular Matrix Extracellular Exosome	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Structural Molecule Activity Protein Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Leukocyte Migration Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Cellular Response To Chemical Stress Energy Homeostasis GDF15-GFRAL Signaling Pathway Response To Metformin Positive Regulation Of Myoblast Fusion	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Axon
Pathways			COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3	14 interacting genes: ARF1 CDC42 CDC42EP3 COPA COPB1 COPG1 COPG2 EFHC2 ERCC6 MBD1 RCHY1 SCYL1 TMED10 WBP2
Entrez ID		9518	11316
HPRD ID		05608	06089
Ensembl ID		ENSG00000130513	ENSG00000105669
Uniprot IDs		Q99988	M0QXB4 O14579
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	6TZT 6U3V
Enriched GO Terms of Interacting Partners?			COPI Vesicle Coat COPI-coated Vesicle COPI-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Coat Transport Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Vesicle Transport Golgi Membrane Vesicle-mediated Transport Intracellular Protein Localization Intracellular Protein Transport Golgi Apparatus Structural Molecule Activity Establishment Of Golgi Localization Intracellular Transport Establishment Of Protein Localization Positive Regulation Of Pseudopodium Assembly Organelle Transport Along Microtubule Golgi Localization Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Protein Transport Microtubule-based Movement Dendritic Spine Organization Transport Along Microtubule Cytoplasmic Vesicle Neuron Projection Organization Postsynapse Organization Cytoskeleton-dependent Intracellular Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Microtubule-based Transport Secretion Response To Metformin Cytoskeletal Regulatory Protein Binding Cytosol To ERGIC Protein Transport Cis-Golgi Network Protein Localization To ERGIC COPI-coated Vesicle Budding Cell Leading Edge Regulation Of Actin Filament Organization Establishment Of Organelle Localization Cleavage Furrow Ingression GBD Domain Binding Storage Vacuole Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
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