GDF15 and SIN3B

		GDF15	SIN3B
Description		growth differentiation factor 15	SIN3 transcription regulator family member B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Extracellular Matrix Extracellular Exosome	Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Autosome Sin3-type Complex
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Chromatin Binding Transcription Corepressor Activity Protein Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Leukocyte Migration Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Cellular Response To Chemical Stress Energy Homeostasis GDF15-GFRAL Signaling Pathway Response To Metformin Positive Regulation Of Myoblast Fusion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Migration Negative Regulation Of DNA-templated Transcription
Pathways			NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3	20 interacting genes: AURKA COPS2 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16
Entrez ID		9518	23309
HPRD ID		05608	09691
Ensembl ID		ENSG00000130513	ENSG00000127511
Uniprot IDs		Q99988	B7Z392 M0QYC5 O75182
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	8BPA 8BPB 8BPC 8C60
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance BBAF Complex DNA Binding Negative Regulation Of Macromolecule Metabolic Process NpBAF Complex NBAF Complex Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Protein-containing Complex Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Epigenetic Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Host-mediated Perturbation Of Viral Transcription Regulation Of Nucleotide-excision Repair SWI/SNF Complex Regulation Of Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of G0 To G1 Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Gene Expression Nucleosomal DNA Binding Regulation Of Sister Chromatid Segregation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of Cell Differentiation Regulation Of Chromosome Segregation Brahma Complex Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Development RSC-type Complex
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