GDF15 and MAST3

		GDF15	MAST3
Description		growth differentiation factor 15	microtubule associated serine/threonine kinase 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Extracellular Matrix Extracellular Exosome	Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Leukocyte Migration Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Cellular Response To Chemical Stress Energy Homeostasis GDF15-GFRAL Signaling Pathway Response To Metformin Positive Regulation Of Myoblast Fusion	Cytoskeleton Organization Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)	A body shape index ( 34021172) Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Body fat mass ( 28552196) Eosinophil percentage of white cells ( 32888494) Glycine levels ( 30837465) Liver enzyme levels (alanine transaminase) ( 33972514) Mental health study participation (completed survey) ( 31263887) Number of sexual partners ( 30643258) Percent liver fat ( 34128465) Red cell distribution width ( 32888494) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006)
Interacting Genes		7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3	2 interacting genes: CNTNAP4 PTEN
Entrez ID		9518	23031
HPRD ID		05608	19403
Ensembl ID		ENSG00000130513	ENSG00000099308
Uniprot IDs		Q99988	A0A8I5KST9 A0A8V8TLL8 A0A8V8TMW0 O60307
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	1V9V 3KHF
Enriched GO Terms of Interacting Partners?			Central Nervous System Neuron Axonogenesis Regulation Of Growth Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Developmental Growth Regulation Of Developmental Growth Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Lung Development Response To Metformin Putamen Development Caudate Nucleus Development Central Nervous System Myelin Maintenance Circadian Rhythm Rhythmic Synaptic Transmission Regulation Of Grooming Behavior Locomotor Rhythm Regulation Of Cell Junction Assembly Cell Projection Morphogenesis Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Cellular Response To Electrical Stimulus Learning Or Memory Negative Regulation Of Growth Regulation Of Locomotion Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Neuron Projection Morphogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Cell Size Presynaptic Membrane Organization Schmidt-Lanterman Incisure Anaphase-promoting Complex Binding Postsynaptic Density Assembly Rhythmic Process Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Axonogenesis Presynaptic Membrane Assembly Nervous System Process GDF15-GFRAL Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Growth Hormone Receptor Signaling Pathway
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