RAB27B and STARD6

		RAB27B	STARD6
Description		RAB27B, member RAS oncogene family	StAR related lipid transfer domain containing 6
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GO Annotations	Cellular Component	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding	Lipid Binding
	Biological Process	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport	Lipid Transport
Pathways		Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Pregnenolone biosynthesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Diastolic blood pressure ( 30224653) Psoriasis ( 23143594 25903422)
Interacting Genes		10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D
Entrez ID		5874	147323
HPRD ID		04846	09518
Ensembl ID		ENSG00000041353	ENSG00000174448
Uniprot IDs		O00194	A0A8I5QL07 P59095
PDB IDs		2F7S	2MOU
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel	Trans-Golgi Network Transport Vesicle Protein Transport Along Microtubule Myosin V Binding Platelet Dense Granule Membrane Zymogen Granule Membrane Anterograde Axonal Protein Transport Multivesicular Body Membrane Exocytic Vesicle Presynaptic Endocytosis Synaptic Vesicle Endocytosis Anterograde Axonal Transport Golgi Stack Multivesicular Body Sorting Pathway Protein Localization To Synapse Axon Cytoplasm Axonal Transport GDP Binding Protein Localization To Cell Junction Positive Regulation Of Exocytosis Axo-dendritic Transport G Protein Activity Vesicle-mediated Transport In Synapse Melanosome Secretory Granule Synaptic Vesicle Membrane Late Endosome Transport Along Microtubule Regulation Of Exocytosis Cytoskeleton-dependent Intracellular Transport Exocytosis Microtubule-based Transport Protein Domain Specific Binding Positive Regulation Of Secretion By Cell GTPase Activity Positive Regulation Of Secretion Apical Plasma Membrane GTP Binding Secretion By Cell Microtubule-based Movement Endocytosis
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