RAB27B and MLPH

Number of citations of the paper that reports this interaction (PMID 11856727)
58

Data Source:
HPRD (in vivo)

		RAB27B	MLPH
Gene Name		RAB27B, member RAS oncogene family	melanophilin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Stack Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Vesicular Exosome	Stress Fiber Microtubule Organizing Center Dendrite Cortical Actin Cytoskeleton Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Actin Binding Rab GTPase Binding Myosin V Binding Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Protein Secretion Melanosome Transport Rab Protein Signal Transduction Positive Regulation Of Exocytosis Multivesicular Body Sorting Pathway	Protein Targeting Melanocyte Differentiation Melanosome Localization
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 21743057)
Protein-Protein Interactions		8 interactors: DHPS MLPH RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D	3 interactors: MYO5A RAB27A RAB27B
Entrez ID		5874	79083
HPRD ID		04846	09409
Ensembl ID		ENSG00000041353	ENSG00000115648
Uniprot IDs		O00194	B3KSS2 G5E9G5 Q9BV36
PDB IDs		2F7S
Enriched GO Terms of Interacting Partners?		Exocytosis Secretion By Cell Secretion Intracellular Protein Transport Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Positive Regulation Of Secretion Protein Localization Regulation Of Exocytosis Regulation Of Secretion Positive Regulation Of Transport Transport Positive Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Deoxyhypusine Biosynthetic Process From Spermidine Granuloma Formation Spermidine Catabolic Process Multivesicular Body Sorting Pathway Peptidyl-lysine Modification To Peptidyl-hypusine Polyamine Catabolic Process Positive Regulation Of Protein Secretion Glucose Homeostasis Natural Killer Cell Degranulation Regulation Of Cellular Localization Chronic Inflammatory Response Positive Regulation Of Mucus Secretion Germinal Center Formation Positive Regulation Of Protein Transport Regulation Of Mucus Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Protein Secretion Natural Killer Cell Activation Involved In Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Mast Cell Degranulation Regulation Of Cell Activation Polyamine Metabolic Process Leukocyte Mediated Cytotoxicity Regulation Of Mast Cell Activation Melanocyte Differentiation Negative Regulation Of Insulin Secretion Regulation Of Regulated Secretory Pathway Melanosome Localization Leukocyte Degranulation Negative Regulation Of Peptide Secretion	Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Cellular Pigmentation Multivesicular Body Sorting Pathway Pigmentation Protein Secretion Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Exocytosis Organelle Localization Melanocyte Differentiation Neuroepithelial Cell Differentiation Secretion By Cell Rab Protein Signal Transduction Developmental Pigmentation Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Secretion Vesicle Docking Membrane Docking Positive Regulation Of Constitutive Secretory Pathway Complement-dependent Cytotoxicity Regulation Of Exocytosis Cellular Protein Localization Protein Transport Vesicle-mediated Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Establishment Of Protein Localization Ras Protein Signal Transduction Intracellular Transport Endoplasmic Reticulum Localization Vesicle Transport Along Actin Filament Exosomal Secretion Protein Localization Positive Regulation Of Secretion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Localization In Cell Natural Killer Cell Degranulation Regulation Of Vesicle-mediated Transport Locomotion Involved In Locomotory Behavior Endomembrane System Organization Secretory Granule Localization T Cell Mediated Cytotoxicity Cellular Localization Epithelial Cell Differentiation Synaptic Transmission
Tagcloud ?		7d autonomous biogenesis contributed deficient dicer disrupt exosomal exosome exosomes foxp3 helper intercellular interference let mechanistic micrornas mirna mirnas providing requirement silencing suppress suppressing suppression th1 transferred treg	blue breeds californian castor checkered coat colour colours cosegregation dilute diluted eumelanic fairy frameshift grey griscelli indel lod marburg melanophilin pearly pheomelanic pigmentation pigmentations rab27a rex segregating sib vienna
Tagcloud (Difference) ?		7d autonomous biogenesis contributed deficient dicer disrupt exosomal exosome exosomes foxp3 helper intercellular interference let mechanistic micrornas mirna mirnas providing requirement silencing suppress suppressing suppression th1 transferred treg	blue breeds californian castor checkered coat colour colours cosegregation dilute diluted eumelanic fairy frameshift grey griscelli indel lod marburg melanophilin pearly pheomelanic pigmentation pigmentations rex segregating sib vienna
Tagcloud (Intersection) ?		rab27a