RAB27B and TUFT1

Data Source: HiPPIP (Novel)

		RAB27B	TUFT1
Name		RAB27B, member RAS oncogene family	tuftelin 1
Structure			No pdb structure
GO Annotations	Cellular Component	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm	Extracellular Region RNA Polymerase II, Core Complex Cytoplasm I Band
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding	Protein Binding Structural Constituent Of Skin Epidermis Structural Constituent Of Tooth Enamel
	Biological Process	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport	Bone Mineralization Biomineral Tissue Development Odontogenesis
Pathways		Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	None
GWAS		Adult body size ( 32376654 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Body mass index ( 28892062 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 26604143 ) Depression ( 29700475 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )	Body mass index ( 26426971 )
Novel Interactors		8 novel interactors: CNPY2 EFHD1 MEX3C NR2E1 SEC11A STARD6 TUFT1 WDR7	1 novel interactors: RAB27B
Interacting Genes		10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D	11 interacting genes: ABCD3 BIRC2 CCDC33 CEP76 KAT5 LMO2 LMO3 NME7 TFIP11 TRIM27 ZYX
Entrez ID		5874	7286
HPRD ID		04846	02516
Ensembl ID		ENSG00000041353	ENSG00000143367
Uniprot IDs		O00194	B7Z4Y1 Q9NNX1
PDB IDs		2F7S	Not available
GO Terms Enriched among Interactors		Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel	Transcription Coactivator Activity