PIGB and SMAD6

Data Source: HiPPIP (Novel)

		PIGB	SMAD6
Name		phosphatidylinositol glycan anchor biosynthesis class B	SMAD family member 6
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Cilium Nuclear Body Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex
	Molecular Function	Alpha-1,2-mannosyltransferase Activity GPI Mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Activin Receptor Binding Type I Activin Receptor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity
	Biological Process	GPI Anchor Biosynthetic Process	Ureteric Bud Development Outflow Tract Septum Morphogenesis Heart Valve Development Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Negative Regulation Of Activin Receptor Signaling Pathway Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Coronary Vasculature Development Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of MiRNA Transcription
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	Signaling by BMP RUNX2 regulates bone development
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Asthma ( 29273806 31959851 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Carpal tunnel syndrome ( 30833571 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Glaucoma (primary open-angle) ( 33627673 ) Height ( 31562340 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) Lung cancer (smoking interaction) ( 24658283 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Refractive error ( 32231278 ) Severe aortic features in Marfan syndrome ( 30087447 ) Subcutaneous adipose tissue ( 22589738 ) Waist-hip ratio ( 25673412 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 )
Novel Interactors		2 novel interactors: RHEB SMAD6	7 novel interactors: ANXA2 MYO1E PIGB PIK3R4 PPIB RAB11A UACA
Interacting Genes		None recorded	17 interacting genes: BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1
Entrez ID		9488	4091
HPRD ID		04988	04240
Ensembl ID		ENSG00000069943	ENSG00000137834
Uniprot IDs		Q92521	O43541
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Zygotic Specification Of Dorsal/ventral Axis Activin Receptor Binding Dorsal/ventral Axis Specification Aortic Valve Morphogenesis Artery Development Ureteric Bud Development I-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Septum Development Heart Valve Development Response To Fluid Shear Stress Heteromeric SMAD Protein Complex Transcription Regulator Inhibitor Activity SMAD Protein Signal Transduction Atrioventricular Valve Morphogenesis Intracellular Signaling Cassette Negative Regulation Of Activin Receptor Signaling Pathway Type I Activin Receptor Binding Negative Regulation Of SMAD Protein Signal Transduction Co-SMAD Binding Pulmonary Valve Morphogenesis Mesonephric Epithelium Development Type I Transforming Growth Factor Beta Receptor Binding Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Ossification Aorta Development Mesonephric Tubule Development R-SMAD Binding Embryonic Axis Specification Response To Laminar Fluid Shear Stress Negative Regulation Of Multicellular Organismal Process Ventricular Septum Development Mitral Valve Morphogenesis Coronary Vasculature Development Protein Sequestering Activity Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Translational Initiation Oligodendrocyte Differentiation Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Translational Initiation Protein Kinase Activator Activity Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Oligodendrocyte Differentiation Response To External Biotic Stimulus Golgi Apparatus Positive Regulation Of MiRNA Transcription Heart Valve Morphogenesis Negative Regulation Of Osteoblast Differentiation Regulation Of SMAD Protein Signal Transduction	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway I-SMAD Binding Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chondrocyte Differentiation Negative Regulation Of BMP Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process BMP Signaling Pathway SMAD Protein Signal Transduction Osteoblast Fate Commitment Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signal Transduction Negative Regulation Of Chondrocyte Proliferation Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Activin Receptor Binding Cellular Response To Growth Factor Stimulus Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Positive Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Protein Kinase Activity Transferase Activity Heteromeric SMAD Protein Complex Positive Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction Protein-containing Complex Regulation Of Metabolic Process Response To Growth Factor Intracellular Signal Transduction Type II Transforming Growth Factor Beta Receptor Binding Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process