CABP1 and CACNA1A

Number of citations of the paper that reports this interaction (PMID 11865310)
56

Data Source:
HPRD (in vivo, in vitro)

		CABP1	CACNA1A
Gene Name		calcium binding protein 1	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Cell Junction Dendrite Neuronal Cell Body Protein Complex Postsynaptic Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Dendrite Cell Projection Neuronal Cell Body
	Molecular Function	Enzyme Inhibitor Activity Calcium Ion Binding Protein Binding Nuclear Localization Sequence Binding Protein Domain Specific Binding Type 3 Metabotropic Glutamate Receptor Binding Protein Homodimerization Activity Ion Channel Binding Calcium-dependent Protein Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Catalytic Activity Negative Regulation Of Voltage-gated Calcium Channel Activity	Sulfur Amino Acid Metabolic Process Glucose Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Neuromuscular Synaptic Transmission Synapse Assembly Adult Walking Behavior Cell Death Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Cell Growth Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Transmission Of Nerve Impulse Spinal Cord Motor Neuron Differentiation Cerebellum Maturation Cerebellar Molecular Layer Development Cerebellar Purkinje Cell Differentiation Vestibular Nucleus Development Cellular Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Regulation Of Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Neurotransmitter Metabolic Process Hormone Metabolic Process Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Behavioral Response To Pain Calcium Ion-dependent Exocytosis Of Neurotransmitter Dendrite Morphogenesis Regulation Of Axonogenesis Regulation Of Insulin Secretion Musculoskeletal Movement, Spinal Reflex Action Neuromuscular Process Controlling Balance Membrane Depolarization Rhythmic Synaptic Transmission Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways			Integration of energy metabolism Regulation of insulin secretion Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs			Pregabalin Verapamil Loperamide Bepridil
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CACNA1A CACNA1C CSNK2A2 FOS GRK5 ITPR1 ITPR3 NMT1 PPP3R1	92 interactors: ABCA2 ABI1 ACTN1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 ASNA1 BTG3 BZRAP1 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LPHN1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TUBB2B UQCRC2 VARS VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		9478	773
HPRD ID		12025	03004
Ensembl ID		ENSG00000157782	ENSG00000141837
Uniprot IDs		C9J8G2 Q9NZU7	B5TYJ1 O00555 Q9NS89
PDB IDs		2K7B 2K7C 2K7D 2LAN 2LAP 3OX5 3OX6	3BXK
Enriched GO Terms of Interacting Partners?		Inositol Phosphate-mediated Signaling Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Energy Reserve Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Regulation Of Cellular Localization Calcium Ion Transport Into Cytosol Cell Death Cytosolic Calcium Ion Transport Death Regulation Of Insulin Secretion Calcium Ion Transmembrane Transport Cell Surface Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Protein Transport Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Signaling Cellular Calcium Ion Homeostasis Calcium Ion Transport Energy Derivation By Oxidation Of Organic Compounds Cell Communication Calcium Ion Homeostasis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Secretion Cellular Metal Ion Homeostasis Cellular Response To Stimulus Generation Of Precursor Metabolites And Energy Apoptotic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Programmed Cell Death Single-organism Behavior Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Metal Ion Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Ion Homeostasis Intrinsic Apoptotic Signaling Pathway Behavior Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Secretion Calcium Ion Import Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Secretion By Cell Secretion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Voltage-gated Calcium Channel Activity Detection Of Visible Light Enzyme Linked Receptor Protein Signaling Pathway Detection Of Light Stimulus Multicellular Organismal Development Phototransduction, Visible Light Anatomical Structure Development Cellular Localization Axon Development Developmental Process Establishment Of Localization In Cell Phototransduction Regulation Of Cellular Process System Development Axonogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Detection Of Abiotic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Degranulation Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Regulation Of Cation Channel Activity Axon Guidance Nervous System Development Detection Of Calcium Ion Regulation Of Intracellular Cholesterol Transport Regulation Of Cell Communication By Electrical Coupling Neuron Projection Morphogenesis Exocytosis Neuron Projection Development Cellular Response To Growth Factor Stimulus Neuron Differentiation Inositol Phosphate Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Cell Part Morphogenesis Response To Growth Factor Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Platelet Activation Cell-cell Signaling Nerve Growth Factor Processing Pathogenesis Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?			acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Difference) ?			acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Intersection) ?