CABP1 and GRK5

Number of citations of the paper that reports this interaction (PubMedID 10625670)
50

Data Source:
BioGRID (pull down)

		CABP1	GRK5
Description		calcium binding protein 1	G protein-coupled receptor kinase 5
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Cytoplasm Golgi Apparatus Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Synapse Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Nuclear Localization Sequence Binding Metal Ion Binding Calcium-dependent Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity
	Biological Process	Visual Perception Negative Regulation Of Protein Import Into Nucleus	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle
Pathways		Sensory processing of sound by inner hair cells of the cochlea	G alpha (q) signalling events G alpha (s) signalling events
Drugs
Diseases
GWAS		C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronotype ( 30696823) Serum metabolite levels ( 33031748) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 33536424)	Appendicular lean mass ( 33097823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31676865 31420334) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: CACNA1A CACNA1C CSNK2A2 FOS GRK5 ITPR1 ITPR3 NMT1 PPP3R1	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		9478	2869
HPRD ID		12025	02926
Ensembl ID		ENSG00000157782	ENSG00000198873
Uniprot IDs		C9J8G2 Q9NZU7	P34947
PDB IDs		2K7B 2K7C 2K7D 2LAN 2LAP 3OX5 3OX6	4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ
Enriched GO Terms of Interacting Partners?		Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Monoatomic Ion Channel Activity Calcium-mediated Signaling Calcium Ion Transmembrane Transport Calcineurin Complex Calcium Ion Transport Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding High Voltage-gated Calcium Channel Activity Cytoplasm Monoatomic Cation Transport Regulation Of Sequestering Of Calcium Ion Calcium Ion Import Across Plasma Membrane Import Across Plasma Membrane Voltage-gated Calcium Channel Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Import Into Cytosol Intracellular Signaling Cassette Monoatomic Ion Transport Voltage-gated Calcium Channel Activity Calcium Ion Import Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Transport Vesicle Membrane Phosphatase Binding Wnt Signaling Pathway Medium-term Memory Cellular Response To Prolactin Release Of Sequestered Calcium Ion Into Cytosol Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Negative Regulation Of Sequestering Of Calcium Ion Myristoyltransferase Activity Renal Phosphate Ion Absorption Inorganic Ion Transmembrane Transport Protein Homotetramerization Sarcoplasmic Reticulum Monoatomic Ion Transmembrane Transport Positive Regulation Of Establishment Of Protein Localization Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Signal Transduction Regulation Of Metal Ion Transport Cerebral Cortex Development	Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior
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