AKAP6 and RYR2

Number of citations of the paper that reports this interaction (PMID 11352932)
61

Data Source:
HPRD (in vivo)

		AKAP6	RYR2
Gene Name		A kinase (PRKA) anchor protein 6	ryanodine receptor 2 (cardiac)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Caveola Junctional Sarcoplasmic Reticulum Membrane Intercalated Disc Sarcoplasmic Reticulum T-tubule Nuclear Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Adenylate Cyclase Binding Protein Complex Scaffold Protein Kinase A Regulatory Subunit Binding Protein Anchor Ion Channel Binding Protein Kinase A Binding	Intracellular Ligand-gated Calcium Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity
	Biological Process	Action Potential Protein Targeting Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Positive Regulation Of Cell Growth Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Phosphatase Type 2B Activity Intracellular Signal Transduction Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of NFAT Protein Import Into Nucleus Regulation Of Membrane Repolarization Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To CAMP Cellular Response To Cytokine Stimulus Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling BMP Signaling Pathway Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Calcium-transporting ATPase Activity
Pathways			Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS		Anorexia nervosa ( 21079607) Economic and political preferences (environmentalism) ( 22566634) Fasting insulin-related traits (interaction with BMI) ( 22581228)	Acute lymphoblastic leukemia (childhood) ( 19684603) Exercise treadmill test traits ( 17903301) Hypertension ( 17554300) Obesity-related traits ( 23251661) Response to cerivastatin ( 21386754) Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		7 interactors: CALM1 CDC5L DISC1 DTNBP1 PDE4D PRKAR2A RYR2	14 interactors: AKAP6 ALB CACNA1C CALM1 FKBP1B HOMER1 ITPR1 MDM2 PRKACA PRKAR2A RYR1 RYR3 SMAD5 SRI
Entrez ID		9472	6262
HPRD ID		05257	01619
Ensembl ID		ENSG00000151320	ENSG00000198626
Uniprot IDs		B2RP22 Q13023	Q92736
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Striated Muscle Contraction Intracellular Signal Transduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Heart Rate By Chemical Signal Regulation Of Cellular Localization Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Adrenergic Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Regulation Of Ion Homeostasis Regulation Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Ion Transport Positive Regulation Of Heart Rate Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Catecholamine Stimulus Muscle Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Cation Channel Activity Muscle System Process Signaling Response To Organonitrogen Compound Cell Communication Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Protein Phosphorylation Activation Of Phospholipase C Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Negative Regulation Of Phosphorylation	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transport Homeostatic Process Muscle Contraction Regulation Of Ion Transmembrane Transport Muscle System Process Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Organic Substance Chemical Homeostasis Response To Organic Cyclic Compound Regulation Of Ion Transport Cytosolic Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cellular Localization Regulation Of Insulin Secretion Regulation Of Establishment Of Protein Localization Regulation Of Striated Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Peptide Hormone Secretion Regulation Of Intracellular Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Localization Regulation Of Hormone Secretion Response To Organonitrogen Compound Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Homeostasis Energy Reserve Metabolic Process Ion Homeostasis Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Cellular Response To Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction
Tagcloud ?		atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly
Tagcloud (Difference) ?		atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly
Tagcloud (Intersection) ?